Migraine ER drug trial halted early – no clear results
NCT ID NCT04726592
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tested whether adding clorazepate (a sedative) to standard migraine medications could provide faster pain relief for people having a migraine attack in the emergency room. The trial included 323 adults with moderate to severe migraine. However, the study was terminated early, so we don't have enough data to know if it worked.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Clorazepate (a sedative) plus usual migraine drugs (ketoprofen and metoclopramide)
- What this could lead to
- If it had worked, this could have pointed to a new option for quickly easing migraine pain in the emergency room.
- What could go wrong
- The trial was terminated early, so we don't have clear evidence it works. It was also a small, single-center study, so results may not apply broadly.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Hôpital Lariboisière
Paris, Île-de-France Region, 75010, France
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