Blood pressure experiment in sepsis halted early – kidney protection still unclear

NCT ID NCT01473498

Terminated Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether raising the blood pressure target from 65 mmHg to 85 mmHg in patients with septic shock could help prevent kidney injury. Researchers used a drug called norepinephrine to adjust blood pressure and monitored kidney function. The trial was stopped early and only included 27 participants, so no firm conclusions can be drawn.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: norepinephrine
What this could lead to: If successful, this approach could point toward a personalized way to manage blood pressure in septic shock to reduce kidney damage.
What could go wrong: The trial was terminated early and enrolled only 27 people, so results are very limited. It is unclear if targeting a higher blood pressure is safe or effective.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute kidney injury Sepsis toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE KIDNEY INJURY SEPTIC SHOCK

Contacts and locations

Locations

Reanimation Chirurgicale - Hôpital Kremlin Bicêtre

Le Kremlin-Bicêtre, France

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