Assistance Publique - Hôpitaux De Paris

This study tests whether regular email reminders and dose adjustments can help people with gout reach safe urate levels and potentially cure the disease. About 204 adults with gout will be assigned to either email-guided care or standard doctor visits. The goal is to see if the e…

This study tests whether myo-inositol, an oral dietary supplement, can help pregnant women with gestational diabetes control their blood sugar and avoid needing insulin shots. About 1,080 women with newly diagnosed gestational diabetes will receive either myo-inositol or a placeb…

This study tests if adding evolocumab (a powerful cholesterol-lowering injection) to standard care helps heart attack patients reach very low LDL cholesterol goals and reduces the risk of death or unplanned hospital visits. About 2,166 adults who had a recent heart attack and nee…

This study tests a minimally invasive procedure called radiofrequency to treat thyroid cancer that has spread to lymph nodes in the neck. It involves 14 adults who have already had surgery and radioactive iodine therapy. The goal is to see if the heat-based treatment can shrink o…

This study tests whether e-cigarettes containing nicotine help people quit smoking better than nicotine-free e-cigarettes or a standard stop-smoking pill called varenicline. About 650 adult smokers who want to quit will be randomly assigned to one of three treatments for 12 weeks…

This study tests whether telling smokers their estimated lung age helps them quit. About 100 adults aged 25+ who have smoked for over a year will either get their lung age calculated or just standard advice. The main goal is to see if more people stop smoking after 6 months, conf…

This study tests a machine that keeps donor hearts alive outside the body for a longer time before transplant. It involves 20 adults with severe heart failure who cannot get a heart through standard methods. The goal is to see if the heart works well within 15 days after the tran…

This study tests whether using a connected scale at home, starting one year after bariatric surgery, can help prevent significant weight regain. About 182 adults who had sleeve or gastric bypass surgery will be randomly assigned to standard follow-up or standard follow-up plus we…

This study aimed to see if adding hydroxychloroquine to standard blood-thinning treatment could help women with antiphospholipid syndrome have a healthy full-term pregnancy. The trial planned to enroll pregnant women before 14 weeks, but it was withdrawn before any participants w…

This study tests whether a blood pressure medication (angiotensin receptor blocker) can reduce the risk of major heart problems and kidney disease in patients who had acute kidney injury while in the intensive care unit (ICU). About 508 adults aged 18-75 who have recovered from a…

This phase 2 trial tests whether giving two immunotherapy drugs (durvalumab and tremelimumab) before and after a standard tumor-burning procedure (ablation) can help prevent liver cancer from coming back. About 30 adults with early-stage liver cancer will receive one infusion of …

This study tests whether adding the drug lenvatinib before and after a standard tumor-burning procedure (ablation) can prevent liver cancer from returning in patients with aggressive tumors. About 32 adults with high-risk features (like high AFP levels or infiltrative tumors) wil…

This study tests whether anakinra is better than prednisone for treating gout flares in people with advanced chronic kidney disease (stage 4 or 5) or who have had a kidney transplant. Gout causes painful joint inflammation, and common treatments like colchicine and NSAIDs are not…

This study looks at over 2,000 children and teens with acute lymphoblastic leukemia (ALL), a blood cancer that is curable in most cases. Researchers are testing two different schedules of a drug called pegaspargase to see which works better and causes fewer side effects. The goal…

This study aimed to see if a web-based service (e-FLS) could help more people over 60 start osteoporosis treatment after a low-trauma fracture, compared to standard care. The trial was withdrawn before any participants were enrolled, so no results are available. It was designed t…

This study tests whether an oral medicine called glibenclamide can control high blood sugar in very premature babies (born before 32 weeks and weighing under 1500 grams). The goal is to see if it can be used instead of insulin, which is the current standard treatment. The study i…

This study tests whether giving a short-term (48-hour) medication to stop contractions can improve survival and reduce severe health problems in babies when the water breaks early (between 22 and 34 weeks of pregnancy). About 857 pregnant people with a single baby and no signs of…

This study looks at adults with sarcoidosis who are in remission after taking the drug infliximab. It compares two strategies: stopping the drug versus continuing it, to see which better prevents the disease from coming back. The goal is to find the safest and most effective way …

This study tests a drug called ivabradine in 429 adults with septic shock, a life-threatening condition where infection causes dangerously low blood pressure. Many patients develop a fast heart rate, which can worsen outcomes. Ivabradine slows the heart without weakening its pump…

This study was designed to test a combination of two immunotherapy drugs (monalizumab and MEDI5752) in people with MSI or dMMR metastatic cancers, which are types of tumors that often respond well to immunotherapy. The trial was withdrawn before enrolling any participants, so no …

This study tests if a drug called mepolizumab can help people with a rare disease called EGPA (which causes inflammation in blood vessels, asthma, and sinus problems) use less steroids while keeping the disease under control. About 100 adults with active EGPA will receive either …

This study tests whether metformin, a common diabetes drug, can slow or prevent calcium buildup in the leg arteries of people with type 1 diabetes. About 230 adults with type 1 diabetes and no severe kidney disease will take either metformin or a placebo for two years. The goal i…

This study tests a new, organized care plan for women at risk of giving birth extremely early (22-26 weeks) and their babies. The goal is to see if this approach helps more babies survive without severe lung, brain, or gut problems. About 2,377 families will take part, with follo…

This study tests whether transplanting healthy stool bacteria can help people with ulcerative colitis, a chronic gut disease. About 150 adults with active symptoms will receive either a fecal transplant or a sham procedure. The goal is to see if this approach can reduce inflammat…

This study aimed to see if giving potassium chloride by IV could help people whose hearts stopped and didn't respond to three electric shocks. It was designed for adults with out-of-hospital cardiac arrest. However, the study was withdrawn before any participants were enrolled, s…

This study was designed to see if the drug eculizumab could treat early, symptom-free rejection in kidney transplant patients. The goal was to prevent long-term damage and graft loss. However, the study was withdrawn before enrolling any participants, so no results are available.

This study aimed to see if a surgery called scleral buckling could prevent retinal detachment (a serious eye problem) in people with Stickler syndrome, a genetic condition that raises the risk. It planned to enroll people aged 5 to 35 who had already lost vision in one eye. Howev…

This study aimed to see if treating the H. pylori stomach infection could prevent ulcers caused by low-dose aspirin in heart patients. It planned to compare three approaches: H. pylori treatment, a stomach acid reducer, or no extra treatment. However, the study was withdrawn befo…

This study tests whether adding a substance called cpFT to the liquid used to grow eggs and embryos can increase the number of live births in women under 37 who are having a type of IVF called ICSI. About 366 couples took part. The goal is to see if this simple change can improve…

This study looks at whether a ketogenic diet (high-fat, low-carb) is practical and safe for people with early-stage Alzheimer's disease over one year. The diet may provide an alternative energy source for the brain and reduce inflammation. Researchers will track diet adherence, b…

This study planned to see how common delirium is in children staying in a pediatric intensive care unit (PICU). Doctors would have used a French version of a standard checklist called the CAPD to screen each child twice a day. The study was withdrawn before any patients were enro…

This study was designed to look back at the safety and effectiveness of hydroxychloroquine given to children with Lipin-1 deficiency, a rare genetic condition that causes severe muscle breakdown and pain. The researchers planned to review medical records of patients who had alrea…

This study aimed to create artificial intelligence models that could diagnose and predict kidney transplant rejection using urine biomarkers, avoiding the need for invasive biopsies. It planned to analyze data from kidney transplant patients followed at Necker Hospital between 20…

This study is collecting blood samples from 500 people with rare brain blood vessel diseases, like CADASIL or moya-moya. The goal is to find new markers that can help doctors predict how the disease will progress and discover new treatment targets. Participants are already part o…

This study was designed to investigate whether new skin lesions on fingers or toes were linked to COVID-19. It planned to test adults with these lesions for the virus using PCR and antibody tests. However, the study was withdrawn before enrolling any participants, so no results a…

This study looks at 150 adults in French intensive care units who have a serious infection in a hip, knee, or shoulder replacement. Researchers will track their care, recovery, and survival for two years to understand what affects outcomes. No new treatments are tested—the goal i…

This study looks at whether a fast, automatic eye test can predict delirium (sudden confusion) in intensive care patients who need a breathing machine. Delirium is common and serious, but current screening methods take time and training. Researchers will measure pupil reactions i…

This study aimed to develop a new questionnaire to better understand how lumbar spinal stenosis limits daily activities. It planned to include patients aged 50 and older with the condition. However, the study was withdrawn before any participants were enrolled, so no results are …

This study looks at whether a detailed analysis of CT scans taken early in treatment can help identify patients with metastatic pancreatic cancer who are not responding to chemotherapy. Researchers will study 400 adults to see if changes in tumor structure can predict survival. T…

This study looks at 100 adults hospitalized in intensive care units with severe pneumonia caused by Mycoplasma or Chlamydia bacteria. Researchers will track how patients are treated, how long they stay in the hospital, and how often the bacteria resist common antibiotics. The goa…

This study was designed to compare certain immune cells (called ILC2) in the lungs of children with severe asthma versus children without asthma. The goal was to see if these cells are higher in asthmatic children and if they relate to other markers of airway inflammation. Howeve…

This study aimed to track heart muscle changes in people with Duchenne muscular dystrophy using MRI scans and blood tests. It planned to enroll children and adults aged 6 and older. However, the study was withdrawn before any participants were enrolled.

This study planned to observe different surgical approaches for children with cataracts, focusing on implant types and surgery timing. It was withdrawn before enrolling any participants, so no information was collected. The goal was to understand which strategies work best for yo…

This study was designed to see how quickly people with hepatitis C in a Paris prison could start antiviral treatment after being locked up. The goal was to reduce delays and prevent the virus from spreading. However, the study was withdrawn before enrolling any participants, so n…

This study was designed to follow women with rare autoimmune diseases (like lupus, arthritis, and scleroderma) during pregnancy to learn about complications and improve care. It was withdrawn before any participants were enrolled, so no results are available. The goal was to help…

This study looks at freezing ovarian tissue in girls with Turner syndrome, a condition that often causes early ovary failure and infertility. Researchers want to find out which patients are most likely to have healthy eggs in their tissue by checking their genes, hormones, and me…

This study aimed to see if a simple breathing test (Müller maneuver) could predict which patients on ventilators would develop fluid in their lungs during a weaning trial. The test measures changes in heart output to assess fluid status. The study was withdrawn before enrolling a…

This study aimed to explore how videoconferencing affects therapeutic education for people with chronic diseases and their caregivers. Researchers planned to interview patients, parents, and healthcare providers to understand their experiences. However, the study was withdrawn be…

This study looks at whether using a connected scale that measures body composition (not just weight) can improve the physical and mental quality of life for people with chronic diseases. About 90 adults will take part in a 6-week physical activity rehab program. Half will use the…

This study planned to train 400 hospital workers each year using realistic emergency drills for children. Researchers wanted to see if the training boosted staff confidence, teamwork, and reduced stress. However, the study was withdrawn before enrolling any participants, so no re…

This study aims to find genetic and metabolic markers that explain why some people develop diabetes, high blood pressure, or bone loss from glucocorticoids while others do not. Researchers will analyze blood and urine samples from up to 600 participants, including those with exce…

This study was designed to observe brain wave (EEG) changes in adults with chronic neuropathic pain during ketamine treatment. Researchers hoped to find patterns that could predict which patients benefit most. However, the study was withdrawn before enrolling any participants, so…

This study aimed to find out if a patient's body language and behavior during a pre-surgery talk with a nurse could reveal their anxiety level. Researchers planned to video record the conversation and compare behaviors to how anxious patients said they felt. The study was withdra…

This study aimed to measure two proteins, ACE2 and TMPRSS2, in tonsils and adenoids of children and adults. These proteins help the COVID-19 virus enter cells. The goal was to understand where the virus might enter the body. However, the study was withdrawn before any participant…

This study follows 69 adults infected with HTLV-1, including those who have developed a rare blood cancer (ATL) and those who have not. Researchers track survival rates over 2 and 5 years and analyze viral and genetic factors. The goal is to better understand how the virus affect…

This study planned to follow male sex offenders with paraphilia for three years to see how well medications like antidepressants or anti-androgens work and what side effects they cause. It aimed to gather real-world data to guide better treatment choices. However, the study was w…

This study was designed to see if a special MRI technique could measure how well a baby's lungs work before birth in cases of diaphragmatic hernia or abdominal wall defects. Researchers planned to compare these MRI results with how the baby breathed after delivery. The study was …

This study planned to find out how often teenagers with juvenile idiopathic arthritis experience chronic pain, especially when their arthritis seems quiet or mild. Researchers wanted to measure pain intensity and how it affects daily life, school, sleep, and social activities. Th…

This study is creating a large group of HIV patients to collect information about their health over time. Researchers will look at heart and brain health, medical history, and how well current HIV medicines work. The goal is to learn more about HIV and improve care, not to test n…

This study was designed to see if a special MRI technique could measure blood flow in the placenta during pregnancy. The goal was to compare placentas in pregnancies where the baby is growing poorly (IUGR) with healthy pregnancies. However, the study was withdrawn before any part…

This study tests a new way to measure movement in infants with spinal muscular atrophy (SMA) who are receiving advanced treatments like gene therapy. Researchers will use small wearable sensors on the arms and legs to track changes in acceleration and speed. The goal is to develo…

This study follows 362 children with severe asthma to learn what makes their asthma worse and how it changes as they grow up. Researchers will also compare them to children with milder asthma. The goal is to find better ways to predict and manage severe asthma, not to test a new …

This study aimed to see if an educational game called Yapouni could help children aged 3 to 16 with severe sleep apnea feel better about using CPAP or NIV breathing machines at night. The plan was to compare standard teaching with teaching plus the game, measuring parents' and ch…

This study looks at whether vaginal self-sampling can effectively detect high-risk HPV in women aged 30-65 with immune-mediated inflammatory diseases like lupus or Sjögren's syndrome. Researchers will track HPV infection rates, types, and clearance over one year. The goal is to i…

This study follows 25 adults with limb-girdle muscular dystrophy 2A (LGMD2A) to measure how their muscle strength and quality of life change over time. Researchers will test arm and leg muscle strength using manual tests and motor scales. The goal is to better understand the natu…

This study looks at how urate-lowering therapy reduces gout crystals in the hands and feet of 50 adults with tophaceous gout. Using a special CT scan, researchers measure crystal shrinkage after 6 months of treatment. The goal is to understand what factors help crystals dissolve …

This study was planned to learn how certain rare genetic mutations disrupt protein production and cause severe diseases affecting the lungs, liver, brain, and digestion. Researchers would have used cells from patients to measure protein levels and stress responses. However, the s…

This study planned to translate and validate a quality-of-life questionnaire (COMQ12) for French-speaking children aged 7 to 15 with chronic otitis media (long-term ear infections). The goal was to help doctors track symptoms and compare treatments. However, the study was withdra…

This study was designed to find out if women can continue breastfeeding after having a breast abscess treated with ultrasound-guided drainage. It planned to follow nursing mothers who had the procedure and ask about their breastfeeding success. However, the study was withdrawn be…

This study planned to test whether a connected toothbrush (ARA 2) helps children with cleft lip and palate keep their mouths cleaner before a bone graft surgery. It aimed to enroll kids aged 5 to 12 who were about to have the surgery. However, the study was withdrawn before any p…

This study tests a new 3D imaging method to measure how much air the lungs can hold in people with suspected diaphragm weakness. About 100 adults will have two quick 3D scans while holding their breath. The goal is to see if this technique gives reliable results compared to stand…

This study was designed to track hidden symptoms like memory or concentration problems in people recovering from a brain bleed (subarachnoid hemorrhage). Researchers planned to follow patients for one year using questionnaires to see how these symptoms affected daily life and ret…

This study looks at whether the standard blood test given to pregnant women to check for fetal genetic conditions can also reveal signs of cancer in the mother. Researchers will analyze DNA from 300 pregnant women who have cancer to identify specific chromosome changes that might…

This study aimed to see if a test measuring how well lung blood vessels widen could predict whether a person with a congenital heart shunt would develop pulmonary hypertension one year after shunt closure. The test involved giving acetylcholine and measuring blood flow. However, …

This study follows 73 young women with breast cancer to see if certain genes make them more likely to lose fertility after chemotherapy. Participants receive standard chemo and have their ovarian reserve checked five years later. The goal is to better understand and predict ferti…

This study aimed to see if a cheap thermal camera attached to a smartphone could accurately measure how deep a child's second-degree burn is. Deep burns often need skin grafts, but it's hard to tell early on. The study was withdrawn before any participants were enrolled, so no re…

This study aimed to look at bone health in young women aged 16 to 25 who took a specific type of birth control pill (macro-progestins) for at least six months. Researchers planned to review medical records and run blood and urine tests to see if these pills affected bone density.…

This study was designed to learn how the protein calprotectin changes blood stem cells in people with severe COVID-19 or certain blood cancers. Researchers planned to compare blood stem cells from patients with severe COVID-19, blood cancers, and healthy volunteers. The study was…

This study tests a therapy where parents of children with autism (ages 1.5 to 3) get video feedback to improve shared attention and interaction. About 27 families will participate, and researchers will measure how much time parent and child spend in joint attention during play. T…

This study is looking at two substances in the blood, called Activin-A and FSTL3, to see if they can help predict how people with pulmonary hypertension will do over time. Researchers will follow 550 adults with different types of this condition to see if these markers are linked…

This study tests a remote monitoring wristband (Bora Care) to see if it can detect early signs of worsening COPD. 64 people with COPD who have had recent flare-ups are being followed. The goal is to see if the device can alert patients and doctors before a serious attack happens.