Diabetes drug metformin may protect leg arteries in type 1 patients

NCT ID NCT04583462

First seen Jan 04, 2026 · Last updated Jun 09, 2026 · Updated 19 times

Summary

This study tests whether metformin, a common diabetes drug, can slow or prevent calcium buildup in the leg arteries of people with type 1 diabetes. About 230 adults with type 1 diabetes and no severe kidney disease will take either metformin or a placebo for two years. The goal is to see if metformin reduces artery calcification, which can lead to poor circulation and amputation.

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Contacts and locations

Locations

  • Pitié Salpêtrière Hospital, AP-HP, Diabetology department

    Paris, 75013, France

Conditions

Explore the condition pages connected to this study.