Blood test may replace painful biopsies for heart transplant patients

NCT ID NCT02672683

Completed Diagnosis Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a simple blood test measuring tiny molecules called microRNAs can spot rejection in heart transplant patients. Researchers tested 461 patients and compared the blood test results with standard heart biopsies. If the blood test works well, it could offer a safer, less invasive way to monitor transplant health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: blood test for microRNAs
What this could lead to: If successful, this could lead to a simple blood test to detect heart transplant rejection, reducing the need for invasive biopsies.
What could go wrong: This is a completed study confirming earlier findings; the test may not be accurate enough to replace biopsies in all patients, and more research is needed before routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC TRANSPLANTATION

Contacts and locations

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Locations

PARCC/ INSERM U970, Team 4, Xavier Jouven, Cardiovascular epidemiology and sudden death, Georges Pompidou European Hospital,

Paris, 75015, France

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