New molecular test could spot heart transplant rejection faster

NCT ID NCT02670408

Recruiting now Knowledge-focused Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study aims to see if a new molecular test can better detect rejection in heart transplant patients compared to standard biopsy analysis. Researchers will collect extra biopsy samples from 900 participants and analyze them using the Molecular Microscope Diagnostic System. The goal is to create a more accurate and timely tool for diagnosing rejection, potentially improving long-term outcomes for transplant recipients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a more accurate and faster way to detect rejection in heart transplant patients, potentially improving their care.
What could go wrong: This is an observational study, not a treatment trial. The new test may not prove more useful than current methods, and results may not change patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC TRANSPLANT DISORDER

Contacts and locations

Locations

Advanced Heart Failure Transplant Unit
COMPLETED

A Coruña, Spain
Alberta Transplant Applied Genomics Center, University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2E1, Canada
Annette C. and Harold C. Simmons Transplant Institute, BaylorScott&White Research Institute
COMPLETED

Dallas, Texas, 75246, United States
Cardiac Transplantation Laboratory, The Victor Chang Cardiac Research Institute
RECRUITING

Darlinghurst, NSW 2010, Australia
Cardiovascular Medicine, University of Utah Health
COMPLETED

Salt Lake City, Utah, 84132, United States
Cedars-Sinai Heart Institute
COMPLETED

Los Angeles, California, 90048, United States
Department of Cardiac Surgery, Medical University of Vienna
RECRUITING

Vienna, A-1090, Austria
Division of Cardiology, University of Alberta
COMPLETED

Edmonton, Alberta, T6G 2R7, Canada
Heart Failure and Heart Transplant Unit, University of Bologna
COMPLETED

Bologna, 40138, Italy
Institute for Clinical and Experimental Medicine - IKEM
RECRUITING

Prague, 14021, Czechia
Service de Néphrologie-Dialyse Adultes , Hôpital Necker-Enfants Malades
COMPLETED

Paris, 75015, France
UCLA Medical Centre
COMPLETED

Los Angeles, California, 90024, United States
Virginia Commonwealth University, Division of Cardiology
COMPLETED

Richmond, Virginia, 23298, United States

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