Pill vs. shot: can glyburide replace insulin for gestational diabetes?

NCT ID NCT01731431

Completed Disease control Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This large study tested whether the diabetes pill glyburide works as well as insulin shots for treating gestational diabetes in 914 pregnant women. The goal was to see if glyburide could prevent newborn complications like high birth weight, low blood sugar, and jaundice. If effective, it could offer a more convenient treatment option.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Glyburide (a pill to lower blood sugar)
What this could lead to: If glyburide works as well as insulin, it could offer a simpler, pill-based option for managing gestational diabetes, reducing the need for injections.
What could go wrong: This trial is complete, but results may not apply to all pregnant women. Glyburide might not control blood sugar as effectively as insulin in some cases, and side effects like low blood sugar are possible.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus gestational diabetes Insulin Resistance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIABETES GESTATIONAL

Contacts and locations

Locations

Marie-Victoire Senat

Paris, 94270, France

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