Could a simple oxygen mask halt rare childhood paralysis attacks?
NCT ID NCT06248645
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether breathing high-flow oxygen for 15 minutes can stop dystonic or plegic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder causing temporary paralysis and muscle spasms. 24 participants used oxygen or a placebo (medical air) during attacks over 5 weeks. The goal was to see if attacks stopped within 30 minutes, offering a potential new acute treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- high-flow oxygen
- What this could lead to
- If it works, this could provide a quick, safe way to stop disabling motor attacks in children with Alternating Hemiplegia of Childhood.
- What could go wrong
- This is a small, early-phase trial with only 24 participants. The effect may not be strong or lasting, and oxygen therapy may not work for everyone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
HCL LYON
Lyon, France
-
Hôpital Pitié Salpêtrière
Paris, 75013, France
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