Special oil may curb paralytic attacks in rare childhood disease
NCT ID NCT02408354
First seen Dec 16, 2025 · Last updated Jun 22, 2026 · Updated 17 times
Summary
This pilot study tested whether triheptanoin oil, a special fat taken by mouth, can reduce the number of sudden paralytic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder. Ten participants aged 15 and older with confirmed ATP1A3 mutations were given either triheptanoin or a placebo in a crossover design. The main goal was to count neurological attacks recorded in patient diaries over 28 weeks.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Groupe hospitalier Pitié Salpêtrière
Paris, 75013, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
triheptanoin oil (a special fat taken by mouth)
What this could lead to
If it works, this could point toward a treatment to reduce the frequency and severity of paralytic episodes in children with Alternating Hemiplegia.
What could go wrong
This is a very small pilot study with only 10 participants, so results may not apply to everyone. The treatment may not reduce attacks or could cause side effects like stomach upset.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.