Special oil may curb paralytic attacks in rare childhood disease
NCT ID NCT02408354
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study tested whether triheptanoin oil, a special fat taken by mouth, can reduce the number of sudden paralytic attacks in children with Alternating Hemiplegia of Childhood (AHC), a rare genetic disorder. Ten participants aged 15 and older with confirmed ATP1A3 mutations were given either triheptanoin or a placebo in a crossover design. The main goal was to count neurological attacks recorded in patient diaries over 28 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- triheptanoin oil (a special fat taken by mouth)
- What this could lead to
- If it works, this could point toward a treatment to reduce the frequency and severity of paralytic episodes in children with Alternating Hemiplegia.
- What could go wrong
- This is a very small pilot study with only 10 participants, so results may not apply to everyone. The treatment may not reduce attacks or could cause side effects like stomach upset.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Groupe hospitalier Pitié Salpêtrière
Paris, 75013, France
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