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New ultrasound method spots tiny brain vessels in stroke patients

NCT ID NCT05785598

Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
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Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI or Doppler ultrasound.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

24 people

The number who actually took part.

Started

Mar 2023

Finished

Mar 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Two groups of patients who benefit from a standard transcranial ultrasound with injection of contrast product (Sonovue) as part of the standard care protocol. On one hand, patients with ischemic stroke, in the absence of middle cerebral artery occlusion and lacunar disease. In this group the perforating arteries are very fine and difficult to visualize by the usual techniques. On the other hand, patients with Moya-moya disease or syndrome. In these patients, there is an overdevelopment of the perforating arteries.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with ischemic stroke hospitalized in the neurology department of the Bichat Hospital in the absence of middle cerebral artery occlusion or lacunar disease. or * Patients followed in the neurology department of the Bichat/Lariboisière hospital with a diagnosis of Moya-Moya disease or syndrome * Patient who has had a TST with contrast injection as part of his follow-up * Patient who has had an MRI as part of his follow-up * Presence of a temporal window that allows ultrasound insonification of the polygon circle of Willis. * Age over 18 years. * Patient not objecting to the analysis of their data Exclusion Criteria: * Patient not affiliated to French Social Security. * Patient under guardianship or curatorship. * Pregnant or breastfeeding patients

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Conditions

The condition(s) this trial relates to.

ischemic stroke Moyamoya disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ischemic stroke Moya moya disease

Contacts and locations

Locations

  • AP-HP, Bichat Hospital

    Paris, Paris, 75010, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.