Could a drug for acromegaly protect kidneys in polycystic disease?
NCT ID NCT02127437
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 3 trial tested whether lanreotide, a drug that blocks certain growth hormones, can slow the loss of kidney function in people with autosomal dominant polycystic kidney disease (ADPKD). The study included 159 adults with moderate kidney decline. Participants received either lanreotide injections or a placebo every 4 weeks for 3 years. The main goal was to see if lanreotide could reduce the rate of kidney function decline by at least 30%.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Lanreotide
- What this could lead to
- If successful, lanreotide could offer a new treatment to slow kidney function loss in people with ADPKD, potentially delaying the need for dialysis or transplant.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet widely confirmed. Lanreotide may not slow kidney decline enough to be clinically meaningful, and side effects like gallstones or injection-site reactions are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Necker hospital
Paris, 75015, France
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Other studies related to the condition(s) this trial covers.
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