Scientists hunt for noninvasive biomarkers to spare children from repeated endoscopies

NCT ID NCT06387030

Recruiting now Knowledge-focused Sponsor: Assistance Publique - Hôpitaux de Paris Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study aims to find noninvasive biomarkers—like substances in urine, blood, or saliva—that can accurately detect active eosinophilic esophagitis in children. Currently, diagnosis and monitoring require repeated endoscopies with biopsies under anesthesia. Researchers will collect samples from 60 children undergoing endoscopy and compare biomarker levels to biopsy results. If successful, this could lead to simpler, less invasive monitoring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to a simple urine or blood test to monitor eosinophilic esophagitis in children, reducing the need for frequent endoscopies under anesthesia.
What could go wrong: This is an early observational study with only 60 children. The biomarkers may not prove accurate enough to replace endoscopies, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

allergic disease eosinophilic esophagitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EOSINOPHILIC ESOPHAGITIS

Contacts and locations

Locations

Nutrition et gastro-entérologie pédiatrique-Trousseau Hospital
RECRUITING

Paris, 75012, France

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