EOSINOPHILIC ESOPHAGITIS

This study tests a new drug, EP-104GI, for adults with eosinophilic esophagitis, a condition that makes swallowing painful and difficult. About 160 participants will receive either the drug or a placebo during an endoscopy. The goal is to see if the drug is safe and reduces infla…

This study tests if taking a 2 mg budesonide tablet once a day works as well as taking 1 mg twice a day for adults with eosinophilic esophagitis, a condition where white blood cells damage the esophagus. About 308 adults with active disease will receive one of the two dosing sche…

This study tests a daily pill called vonoprazan against a placebo in 80 adults with eosinophilic esophagitis, a condition where food allergies cause throat inflammation and trouble swallowing. The main goal is to see if the drug reduces allergic cells in the throat after 12 weeks…

This study tests a drug called Zemaira in 15 adults with eosinophilic esophagitis, a condition where the esophagus becomes inflamed and swollen. The goal is to see if Zemaira can reduce inflammation and improve symptoms. Participants receive the drug for 4 weeks and are monitored…

This study aims to see if a simple, low-cost esophageal string test can accurately diagnose eosinophilic esophagitis (EoE), a condition causing swallowing trouble. Researchers will compare the string test results with standard endoscopy in 70 African adults with dysphagia in Mali…

This study will test a new FDA-approved device that measures electrical resistance in the esophagus to diagnose GERD and eosinophilic esophagitis. Researchers want to see if it can replace multiple tests, saving time and money. About 50 adults with chronic reflux or swallowing pr…

This study looks at whether children with eosinophilic esophagitis (EoE) can eat heated forms of hen's egg or cow's milk without their disease coming back. About 36 kids who are currently avoiding these foods will try gradually introducing more heated versions, like baked egg or …

This study follows 150 adults with eosinophilic esophagitis (EoE) who are starting dupilumab as part of their normal care. Researchers will collect information on medical history, symptoms, quality of life, and any side effects over two years. The goal is to understand how well d…

This study is testing a new tool to help adults with eosinophilic esophagitis (EoE) learn about their treatment options and make decisions about their care. About 40 people from the University of Michigan will try the tool or receive general education. The goal is to see if the t…

This study looks at different ways to measure how well people with eosinophilic disorders (like EoE) are doing. Researchers will compare tissue samples from endoscopies with patient questionnaires to see if simpler tests can replace invasive procedures. The goal is to find the be…

This study aims to learn more about what causes food allergies and related conditions like eczema and eosinophilic esophagitis. Researchers will follow up to 1,800 people aged 2 to 99, including those with allergies, their relatives, and healthy volunteers, for up to 12 years. Pa…

This study aims to learn more about a newly described condition called FIRE (Food Induced Immediate Response of the Esophagus) in children aged 6 to 17 who already have eosinophilic esophagitis. Researchers want to find out how common FIRE is and what symptoms it causes, such as …

This small study looks at whether treating inflammation in the esophagus with proton pump inhibitors (acid-reducing drugs) improves the organ's ability to stretch and function. Researchers will measure flexibility in both the upper and lower esophagus before and after treatment i…

This study creates a registry of up to 500 people with eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis, gastroenteritis, and colitis. Researchers will collect medical information, symptom reports, and tissue samples during routine care to learn…

This study is a registry that will gather information from up to 10,000 adults with esophageal problems like GERD, achalasia, or swallowing difficulties. Researchers will collect data from standard tests such as manometry and pH monitoring to better understand these conditions. T…

This study is testing whether measuring a protein called EDN in urine, blood, or esophageal brushings can help monitor eosinophilic esophagitis in children without needing repeated endoscopies. Researchers will collect samples from 60 children undergoing upper GI endoscopy for di…