New injection could ease swallowing for eosinophilic esophagitis patients
NCT ID NCT05608681
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new injectable steroid called EP-104GI for adults with eosinophilic esophagitis, a condition where the esophagus becomes inflamed and makes swallowing difficult. The drug is given during an endoscopy and is designed to release medication slowly over time. The trial involves about 160 participants and will check for safety, side effects, and whether it improves symptoms and reduces inflammation in the esophagus.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- EP-104GI (extended-release fluticasone propionate injection)
- What this could lead to
- If successful, this could provide a longer-lasting treatment option for eosinophilic esophagitis, reducing the need for daily medication.
- What could go wrong
- This is an early-phase trial with a small number of participants, so results may not apply to everyone. The drug is a steroid, which can have side effects like adrenal suppression.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for EOSINOPHILIC ESOPHAGITIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Amsterdam UMC
ACTIVE_NOT_RECRUITINGAmsterdam, 1105, Netherlands
-
Aotearoa Clinical Trials
RECRUITINGPapatoetoe, Auckland, New Zealand
-
Campbelltown Private Hospital
RECRUITINGSydney, New South Wales, Australia
-
Capital Coast and Hutt
RECRUITINGLower Hutt, New Zealand
-
Cardiff and Vale University Health Board-Wales
RECRUITINGCardiff, United Kingdom
-
Coastal Digestive Health
RECRUITINGMaroochydore, Queensland, Australia
-
Eastern Health Box Hill
RECRUITINGBox Hill, Victoria, 3128, Australia
-
Erasmus University Medical Center
RECRUITINGHolland, Netherlands
-
G.I. Research Institute
RECRUITINGVancouver, British Columbia, V6Z 2K5, Canada
-
Mater Hospital Brisbane
RECRUITINGBrisbane, Queensland, Australia
-
McGill University Health Center
RECRUITINGMontreal, Quebec, Canada
-
Norfolk and Norwich University Hospital
RECRUITINGNorwich, Norfolk, United Kingdom
-
Northern Hospital Epping
RECRUITINGEpping, Victoria, Australia
-
Princess Alexandra Hospital
RECRUITINGBrisbane, Queensland, Australia
-
Royal Adelaide Hospital
RECRUITINGAdelaide, South Australia, Australia
-
Royal Liverpool University Hospital
RECRUITINGLiverpool, United Kingdom
-
Royal Melbourne Hospital
RECRUITINGParkville, Victoria, Australia
-
St George's University of London
RECRUITINGLondon, United Kingdom
-
The Alfred Hospital
RECRUITINGMelbourne, Victoria, Australia
-
University of Calgary
RECRUITINGCalgary, Alberta, Canada
-
Universitätsspital Zürich
RECRUITINGZurich, Switzerland
-
UoA - South Edmonton Gastroenterology Research Clinic
RECRUITINGEdmonton, Alberta, Canada
-
Waikato Hospital
RECRUITINGHamilton, New Zealand
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Swallowable sponge could replace endoscopy for esophagitis monitoring
- Blood tests may replace scopes for EoE diagnosis
- Massive new registry aims to crack the code on mysterious gut disorders
- 300 kids with EoE enrolled in landmark database study
- Could ditching milk soothe a painful esophagus? new trial tests Diet-Only approach
- Can cutting four foods ease Kids' esophagus inflammation?