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Swallowable sponge could replace endoscopy for esophagitis monitoring

NCT ID NCT06501274

Disease control Sponsor: East and North Hertfordshire NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study tests a capsule sponge device as a less invasive alternative to endoscopy for checking how well treatment is working in people with eosinophilic esophagitis (a chronic allergic condition of the esophagus). Participants swallow a capsule attached to a string, which expands into a sponge to collect cell samples. The trial will compare the sponge's results with symptom questionnaires and see if it changes treatment decisions. It also measures patient pain and preference.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
capsule sponge
What this could lead to
If successful, this could offer a simpler, less invasive way to monitor treatment response in eosinophilic esophagitis, reducing the need for repeated endoscopies.
What could go wrong
This is a small, single-site study. The capsule sponge may not provide enough tissue for analysis, and some patients may not be able to swallow it. It is not a treatment, only a monitoring tool.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

143 people

The number who actually took part.

Started

Jul 2023

Finished

Dec 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: • patients diagnosed with non -stenotic eosinophilic oesophagitis who have a change in treatment Exclusion Criteria: * Strictures or rings at most recent endoscopy that prevent passage of adult gastroscope * Previous oesophageal dilatation * Previous oesophageal perforation or surgical resection * Oesophago-gastric malignancy * Oesophageal varices * Bolus obstruction since last endoscopy requiring hospital visit * Previous fundoplication or complicated hiatus hernia * Patient on Warfarin with INR\>=3 * Suspected new diagnosis of EOE without prior endoscopic confirmation

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Conditions

The condition(s) this trial relates to.

eosinophilic esophagitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Eosinophilic esophagitis

Contacts and locations

Locations

  • East and North Herts NHS Trust

    Stevenage, Hertfordshire, SG1 4AB, United Kingdom

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