Tiny study tests if PPIs loosen a stiff esophagus

NCT ID NCT03312686

Recruiting now Knowledge-focused Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study at Indiana University will test whether a 2-month course of high-dose proton pump inhibitors (PPIs) can improve the flexibility (distensibility) of the esophagus in 10 people with eosinophilic esophagitis (EoE). Researchers will measure flexibility in both the upper and lower esophagus before and after treatment, and see if changes relate to reduced inflammation. The goal is to better understand how treating inflammation affects swallowing function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: proton pump inhibitors (PPIs)
What this could lead to: If successful, this could show that treating inflammation with PPIs improves esophagus flexibility, potentially guiding better management of swallowing difficulties.
What could go wrong: This is a very small pilot study with only 10 participants, so results may not apply to everyone. It is designed to gather information, not to prove a treatment works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

eosinophilic esophagitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EOSINOPHILIC ESOPHAGITIS

Contacts and locations

Locations

Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Indiana University Health University Hospital
RECRUITING

Indianapolis, Indiana, 46202, United States

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