Tiny study tests if PPIs loosen a stiff esophagus
NCT ID NCT03312686
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study at Indiana University will test whether a 2-month course of high-dose proton pump inhibitors (PPIs) can improve the flexibility (distensibility) of the esophagus in 10 people with eosinophilic esophagitis (EoE). Researchers will measure flexibility in both the upper and lower esophagus before and after treatment, and see if changes relate to reduced inflammation. The goal is to better understand how treating inflammation affects swallowing function.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
proton pump inhibitors (PPIs)
What this could lead to
If successful, this could show that treating inflammation with PPIs improves esophagus flexibility, potentially guiding better management of swallowing difficulties.
What could go wrong
This is a very small pilot study with only 10 participants, so results may not apply to everyone. It is designed to gather information, not to prove a treatment works.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
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Indiana University Health University Hospital
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact
Contact Email: •••••@•••••