Cord blood stem cells aim to repair hearts after attack
NCT ID NCT07134712
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new treatment called MiSaver, made from umbilical cord blood cells, for people who recently had a heart attack. The goal is to see if it safely helps the heart pump better and reduces future heart problems. About 102 participants will either receive the cell treatment or standard care, and their heart function will be tracked for a year.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 102 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Mar 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Age ≥ 45 years, BMI ≤ 32 2. Patients diagnosed with acute myocardial infarction by a cardiologist, within 36 hours to 7 days post-diagnosis, and able to complete cell infusion within this period. 3. Left ventricular ejection fraction (LVEF) ≤ 45%, hemodynamically stable patients who do not require vasopressor support within 24 hours. 4. Patients with a history of coronary artery disease, who have previously undergone percutaneous coronary intervention or coronary artery bypass graft surgery, may also be included upon evaluation by a cardiologist. 5. Patients deemed unsuitable for percutaneous coronary intervention or coronary artery bypass graft surgery by a cardiologist. 6. Must agree to sign the informed consent form. 7. Subjects must use effective contraception during the study observation period and for 6 months after its conclusion to ensure no pregnancy occurs during the study. (Primarily for women of childbearing potential). 8. Agree to and comply with the required outpatient visits and examinations during the study observation period. Exclusion Criteria: 1. Age \< 45 years, BMI \> 32. 2. Women who are planning to become pregnant, are pregnant, or are breastfeeding 3. Immunodeficiency diseases caused by infection , such as Human Immunodeficiency Virus (HIV). 4. Patients diagnosed as needing coronary artery bypass surgery or potentially requiring coronary revascularization surgery within the next 6 months. 5. Severe aortic or mitral valve stenosis. 6. Life-threatening arrhythmias. 7. Malignant tumors, including all categories and cancer conditions. 8. Hematologic disorders or other severe organ diseases with an expected survival of less than one year. 9. Chronic kidney disease (eGFR \< 30 mL/min/1.73m²) or patients undergoing dialysis. 10. Patients with autoimmune diseases or those who have already received immunotherapy. 11. Patients who have undergone tumor treatment or require immunosuppressive therapy within the last three years. 12. History of transfusion reactions. 13. Recipients of bone marrow or organ transplants. 14. Liver dysfunction (bilirubin \> 2.5 mg/dL or transaminases \> 5x the upper limit of normal). 15. Patients who have previously received growth factors, cytokines, gene therapy, or stem cell therapy. 16. Subjects participating in more than one clinical trial. 17. Inability to sign the consent form or comply with outpatient follow-up after infusion therapy. 18. Patients with a known allergy to this product or its excipients (e.g., dimethyl sulfoxide, cell preservation solution).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
4 sites in 2 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Chung Shan Medical University Hospital Daqing Branch
Taichung, Taiwan
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Flinders Medical Centre
Bedford Park, South Australia, 5042, Australia
Contact Email: •••••@•••••
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Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
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Mackay Memorial Hospital Hsinchu Branch
Hsinchu, Taiwan
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