New shot before angioplasty may shield heart attack patients

NCT ID NCT06683131

Not yet recruiting Disease control Sponsor: The Affiliated Hospital of Xuzhou Medical University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether starting the drug tafolecimab (a PCSK9 inhibitor) just before emergency angioplasty can lower the chance of major heart problems over the next year in people having a heart attack. About 1,160 adults will either get the drug plus standard care or standard care alone. The drug is given as a shot before the procedure and then every two weeks for a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tafolecimab (a PCSK9 inhibitor drug given by injection)
What this could lead to: If it works, this could provide a new treatment option to reduce the risk of future heart problems after a heart attack.
What could go wrong: This is a Phase 4 trial, so the drug is already approved for other uses, but its benefit in this specific setting is unproven. Side effects from injections or the drug itself are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYOCARDIAL INFARCTION (AMI)

Contacts and locations

Locations

Jiangsu Provincial Hospital of Traditional Chinese Medicine

Nanjing, Jiangsu, China
Jiangsu Provincial People's Hospital (The First Affiliated Hospital of Nanjing Medical University)

Nanjing, Jiangsu, China
Lianyungang Municipal Dongfang Hospital

Lianyungang, Jiangsu, China
Peking University First Hospital

Beijing, 100000, China
Shanghai Tenth People's Hospital

Shanghai, China
Suining County People's Hospital

Xuzhou, Jiangsu, China
Suqian Hospital of Jiangsu Provincial People's Hospital

Suqian, Jiangsu, China
Taihe County People's Hospital

Fuyang, Anhui, China
The Fifth People's Hospital of Huai'an City

Huai'an, Jiangsu, China
The Fourth Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China
The affiliated hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221006, China
Xuzhou Central Hospital

Xuzhou, Jiangsu, China
Xuzhou Mining Group General Hospital

Xuzhou, Jiangsu, China

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