Cooling the heart during a heart attack: a trial that never got started

NCT ID NCT03361995

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study planned to test whether cooling the body before and after opening a blocked artery could help people having a heart attack. It was designed to include 80 patients at up to 15 hospitals. However, the trial was withdrawn before anyone was enrolled, so we have no information on whether cooling is helpful or safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Cooling procedure using the ZOLL Thermogard XP3 IVTM System

What this could lead to

If it had worked, cooling might have reduced heart damage during a heart attack, potentially improving recovery.

What could go wrong

The trial was withdrawn before any patients were enrolled, so we have no data on whether cooling is safe or effective. Cooling also carries risks like shivering, infection, or heart rhythm problems.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction anterolateral myocardial infarction ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.