Ambulance injection could improve heart attack outcomes

NCT ID NCT04825743

Ongoing Disease control Sponsor: CeleCor Therapeutics Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 23 times

Summary

This study tests a single injection of zalunfiban given by paramedics to people having a severe heart attack (STEMI) before they reach the hospital. About 2,463 adults will receive either one of two doses of the drug or a placebo. The goal is to see if the drug improves blood flow and reduces complications like death, stroke, or another heart attack within 30 days.

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Contacts and locations

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Locations

Amphia Ziekenhuis

Breda, Netherlands
Amsterdam UMC

Amsterdam, Netherlands
Amsterdam UMC, locatie AMC

Amsterdam, Netherlands
André Grégoire Hospital - GHT GPNE

Montreuil, France
Bacs-Kiskun County Teaching Hospital

Kecskemét, Hungary
Baylor College of Medicine

Houston, Texas, 77030, United States
Bichat-Claude Bernard Hospital

Paris, France
Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States
ETZ TweeSteden

Tilburg, Netherlands
Emergency Clinical County Hospital Targu-Mures

Târgu Mureş, Romania
Emergency Clinical Hospital "Bagdasar-Arseni", Bucharest

Bucharest, Romania
Emergency University Hospital Bucharest

Bucharest, Romania
European Hosital de Paris - GVM Care & Research (La Roseraie)

Aubervilliers, France
Grenoble Alpes University Hospital

Grenoble, France
Henri Mondor University Hospital

Créteil, France
Hospital Ambroise Pare

Boulogne-Billancourt, 92100, France
Hôpital Cochin

Paris, France
Institute for Cardiovascular Diseases Timisoara

Timișoara, Romania
Institute of Cardiovascular Diseases "Prof. George I.M. Georgescu" Iasi

Iași, Romania
Instituto Nacional de Cardiologia "Ignacio Chavez"

Mexico City, D.F., 14080, Mexico
Isala

Zwolle, Netherlands
Jeroen Bosch Ziekenhuis

's-Hertogenbosch, Netherlands
Lariboisière Hospital AP-HP

Paris, France
Leiden University Medical Center

Leiden, Netherlands
Maastricht UMC

Maastricht, Netherlands
Medisch Spectrum Twente

Enschede, Netherlands
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Regional University Hospital of Rennes - Hospital Ponchaillou

Rennes, France
Rijnstate Arnhem

Arnhem, Netherlands
Semmelweis University Heart and Vascular Center

Budapest, Hungary
Slingeland Ziekenhuis

Doetinchem, Netherlands
St. Anne's University hospital

Brno, Czechia
St. Antonius Ziekenhuis

Nieuwegein, 3435 CM, Netherlands
Tergooi Blaricum

Blaricum, Netherlands
UMC Utrecht

Utrecht, Netherlands
UT Southwestern Medical Center

Dallas, Texas, 75390, United States
University Hospital Brno

Brno, Czechia
University Hospital De La Pitié-Salpêtrière

Paris, France
University Hospital of Marseille - La Timone Hospital

Marseille, France
University of Alberta

Edmonton, Canada
University of Debrecen

Debrecen, H4032, Hungary
Viecuri Medisch Centrum

Venlo, Netherlands
Washington University

St Louis, Missouri, 63110, United States
Ziekenhuis Gelderse Vallei

Ede, Netherlands
Zuyderland MC

Heerlen, Limberg, Netherlands

Conditions

Explore the condition pages connected to this study.

ST ELEVATION MYOCARDIAL INFARCTION (STEMI) ST-ELEVATION MYOCARDIAL INFARCTION (STEMI)