Heart attack drug targets tiny vessels, not blockages

NCT ID NCT05198791

Recruiting now Disease control Sponsor: NHS National Waiting Times Centre Board Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tests whether eplerenone, a drug used for high blood pressure and heart failure, can help people who have had a heart attack or heart injury but no blocked arteries. Many of these patients have damage to tiny blood vessels in the heart. The study will involve 400 adults in Scotland. Participants with small vessel problems will either get eplerenone or usual care for six months. The main goal is to see if the drug reduces heart injury markers and improves heart function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Eplerenone (a tablet that reduces blood vessel injury, used for high blood pressure and heart failure)
What this could lead to: If it works, this could point toward a treatment for heart damage caused by small vessel problems after a heart attack.
What could go wrong: This is an early phase 2 trial with only 400 participants, so results may not apply to everyone. The drug may not reduce heart injury or improve outcomes as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction MINOCA myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOCARDIAL INFARCTION WITH NONOBSTRUCTIVE CORONARY ARTERIES MYOCARDIAL INFARCTION, ACUTE MYOCARDIAL INJURY

Contacts and locations

Locations

Golden Jubilee National Hospital
RECRUITING

Glasgow, United Kingdom
University Hospital Hairmyres
RECRUITING

East Kilbride, Lanarkshire, G75 8RG, United Kingdom

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