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Can a new anesthetic shield elderly hearts during surgery?

NCT ID NCT07725185

Disease control Sponsor: Affiliated Hospital of Jiaxing University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 24, 2026 · Last updated Aug 26, 2026 · Updated 2 times

Summary

This trial compares two anesthetic drugs—remimazolam and propofol—to see which one better protects the heart in elderly patients undergoing general anesthesia. Researchers will measure heart function and levels of a heart injury marker after surgery. The goal is to find out if remimazolam can reduce the risk of postoperative heart damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
remimazolam or propofol, two anesthetic drugs given intravenously during surgery
What this could lead to
If remimazolam proves better at protecting the heart, it could become a preferred anesthetic for elderly patients undergoing long surgeries.
What could go wrong
This is a small, early-stage trial with 80 participants, so results may not apply broadly. Both drugs have known side effects like low blood pressure or slow heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 65 years * Elderly hospitalized patients scheduled to undergo general anesthesia * American Society of Anesthesiologists (ASA) physical status I-III * Surgery to be performed in the supine position * Ability to communicate with the investigator and to cooperate in completing the assessment scales * Expected duration of surgery ≥ 2 hours Exclusion Criteria: * Congenital heart disease, severe cardiac conduction block, or implanted cardiac pacemaker; * History of cerebral infarction, cerebral hemorrhage, or stroke within the past 3 months; * Known allergy to remimazolam or propofol; * Severe mental illness, history of analgesic abuse, or addiction to psychotropic drugs; * Patient or family members refuse surgery or anesthesia, or are unable to complete the required questionnaires.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myocardial injury

How to take part

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  2. The official record

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Contacts and locations

Locations

  • Jiaxing University Affiliated Hospital

    Jiaxing, Zhejiang, 314000, China

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