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Can new imaging and genetics unlock the secrets of heart attacks?

NCT ID NCT07772570

Knowledge-focused Sponsor: University of Oxford Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 25, 2026 · Updated 3 times

Summary

This study aims to understand why fatty plaques in heart arteries suddenly rupture, causing heart attacks, and why some people experience more heart muscle damage than others. Researchers will use advanced imaging, blood tests, and genetic analysis in about 2,000 patients undergoing heart procedures. By combining these detailed measurements, they hope to build a complete picture of the disease process and identify new ways to predict, diagnose, and treat heart attacks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood sampling, intracoronary imaging, cardiac MRI, CT, and coronary physiology measurements
What this could lead to
If successful, this could lead to better ways to predict, diagnose, and treat heart attacks, potentially reducing heart damage and improving patient outcomes.
What could go wrong
This is an observational study, so it won't directly test a new treatment. The findings may take years to translate into clinical practice, and the complex data may not yield clear answers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2012

Expected to finish

Dec 2046

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients presenting with evidence of myocardial injury (e.g. elevation of troponin or other cardiac biomarkers, ECG changes, wall motion abnormalities on cardiac imaging) AND/OR referred for coronary angiography with view to proceed to PCI as indicated in either non-emergency or emergency settings.

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Evidence of myocardial injury (e.g. elevation of troponin or other cardiac biomarkers, ECG changes, wall motion abnormalities on cardiac imaging) AND/OR referred for coronary angiography with view to proceed to PCI as indicated in either non-emergency or emergency settings. Exclusion Criteria: * Patients in whom safety or clinical concerns preclude participation. * Anaemia (Hb \<9). * Pregnant or breast feeding females. Additional exclusion criteria for patients undergoing MRI * claustrophobia which limits / prevents participants from remaining in MRI scanner. * patients who cannot lie flat on the scan table. * patients with metallic implants, pacemakers, implantable defibrillators etc, unless known to be MRI compatible. * patients with known allergy to medium of contrast (gadolinium) Additional exclusion criteria for patients undergoing coronary CT angiography * patients with a known allergy to iodinated contrast media * eGFR\< 30 ml/min (stage 3-5 renal disease)

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Conditions

The condition(s) this trial relates to.

acute myocardial infarction atherosclerotic cardiovascular disease coronary artery disorder thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atherosclerosis cardiovascular disease Biomarker discovery Cardiac imaging techniques Coronary physiology Genetics Intravascular imaging and microvascular obstruction Myocardial injury Thrombus Trained immunity

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Oxford Heart Centre, John Radcliffe Hospital

    RECRUITING

    Oxford, United Kingdom

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