Which blood thinner combo best prevents a second stroke?

NCT ID NCT06591338

Recruiting now Disease control Sponsor: Kafrelsheikh University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 trial compares two anti-clotting drug combinations—aspirin plus ticagrelor versus aspirin plus clopidogrel—in 900 adults who recently had a minor stroke or transient ischemic attack (TIA) caused by a large artery blockage. Participants receive the drugs within 24 hours of their event and are followed for 90 days to see which combination better prevents new strokes, heart attacks, or death, while also tracking bleeding side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin plus ticagrelor or clopidogrel
What this could lead to: If successful, this could show that aspirin plus ticagrelor is better than aspirin plus clopidogrel at preventing another stroke after a minor stroke or TIA.
What could go wrong: This is a single-center trial in Egypt, so results may not apply worldwide. Both drug combinations increase bleeding risk, and the study is still recruiting, so final results are years away.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemic stroke large artery stroke transient ischemic attack

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ISCHEMIC STROKE

Contacts and locations

Locations

Kafr Elsheikh University Hospital
RECRUITING

Kafr ash Shaykh, 33511, Egypt

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