New pacemaker setting aims to cut irregular heartbeat risk

NCT ID NCT07608822

Recruiting now Knowledge-focused Sponsor: Biotronik SE & Co. KG Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study is observing 150 people who have a pacemaker with a special setting called Closed Loop Stimulation (CLS) combined with left bundle branch area pacing. The goal is to see if this setting reduces the occurrence of atrial fibrillation over two years. Participants have sinus node disease or heart block and are already enrolled in a larger registry. The study will track device-detected atrial fibrillation episodes and heart rate patterns.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Left bundle branch area pacing with Closed Loop Stimulation (pacemaker device)
What this could lead to: If successful, this could show that a specific pacemaker setting reduces the risk of atrial fibrillation in people with certain heart rhythm problems.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all patients, and the device may not reduce atrial fibrillation as hoped.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrioventricular block sick sinus syndrome sinoatrial node disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIOVENTRICULAR BLOCK SINUS NODE DISEASE

Contacts and locations

Locations

A.O.U. Maggiore della Carita di Novara
RECRUITING

Novara, Italy
Fondazione Policlinico Universitario "Agostino Gemelli" Università Cattolica del Sacro Cuore
NOT_YET_RECRUITING

Roma, Italy
Hospital Universitario 12 de Octubre
NOT_YET_RECRUITING

Madrid, Spain
Hospital Universitario La Fe
NOT_YET_RECRUITING

Valencia, Spain
Masarykova nemocnice v Usti nad Labem
NOT_YET_RECRUITING

Ústí nad Labem, Czechia
Niguarda hospital
NOT_YET_RECRUITING

Milan, Italy
Ospedale Di Summa - Perrino
NOT_YET_RECRUITING

Brindisi, Italy
Ospedale di Piove di Sacco
NOT_YET_RECRUITING

Piove di Sacco, Italy
SS Annunziata Taranto
NOT_YET_RECRUITING

Taranto, Italy
Semmelweis University
NOT_YET_RECRUITING

Budapest, Hungary
Unidade local de Saúde de Coimbra, EPE - Centro Hospitalar Universitario de Coimbra
NOT_YET_RECRUITING

Coimbra, Portugal
University of Szeged
NOT_YET_RECRUITING

Szeged, Hungary

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