New pacemaker setting aims to cut irregular heartbeat risk
NCT ID NCT07608822
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is observing 150 people who have a pacemaker with a special setting called Closed Loop Stimulation (CLS) combined with left bundle branch area pacing. The goal is to see if this setting reduces the occurrence of atrial fibrillation over two years. Participants have sinus node disease or heart block and are already enrolled in a larger registry. The study will track device-detected atrial fibrillation episodes and heart rate patterns.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Left bundle branch area pacing with Closed Loop Stimulation (pacemaker device)
What this could lead to
If successful, this could show that a specific pacemaker setting reduces the risk of atrial fibrillation in people with certain heart rhythm problems.
What could go wrong
This is an observational study, not a controlled trial, so it cannot prove cause and effect. Results may not apply to all patients, and the device may not reduce atrial fibrillation as hoped.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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A.O.U. Maggiore della Carita di Novara
RECRUITINGNovara, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fondazione Policlinico Universitario "Agostino Gemelli" Università Cattolica del Sacro Cuore
NOT_YET_RECRUITINGRoma, Italy
Contact Email: •••••@•••••
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Hospital Universitario 12 de Octubre
NOT_YET_RECRUITINGMadrid, Spain
Contact Email: •••••@•••••
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Hospital Universitario La Fe
NOT_YET_RECRUITINGValencia, Spain
Contact Email: •••••@•••••
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Masarykova nemocnice v Usti nad Labem
NOT_YET_RECRUITINGÚstí nad Labem, Czechia
Contact Email: •••••@•••••
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Niguarda hospital
NOT_YET_RECRUITINGMilan, Italy
Contact Email: •••••@•••••
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Ospedale Di Summa - Perrino
NOT_YET_RECRUITINGBrindisi, Italy
Contact Email: •••••@•••••
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Ospedale di Piove di Sacco
NOT_YET_RECRUITINGPiove di Sacco, Italy
Contact Email: •••••@•••••
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SS Annunziata Taranto
NOT_YET_RECRUITINGTaranto, Italy
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Semmelweis University
NOT_YET_RECRUITINGBudapest, Hungary
Contact Email: •••••@•••••
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Unidade local de Saúde de Coimbra, EPE - Centro Hospitalar Universitario de Coimbra
NOT_YET_RECRUITINGCoimbra, Portugal
Contact Email: •••••@•••••
Contact
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University of Szeged
NOT_YET_RECRUITINGSzeged, Hungary
Contact Email: •••••@•••••