New heart failure drug enters early human testing
NCT ID NCT07465653
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing an experimental drug called HJB647 in 12 adults with stable chronic heart failure and reduced pumping ability. The study aims to check the drug's safety and how the body processes it at two different doses. Participants will receive both the drug and a placebo at different times to compare effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HJB647 (an experimental drug in capsule form)
What this could lead to
If successful, this could point toward a new treatment option for chronic heart failure with reduced ejection fraction.
What could go wrong
This is a very early Phase 1 trial with only 12 participants, so it is primarily testing safety, not effectiveness. The drug may not work or could have side effects.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-••••
Locations
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Jacksonville Center for Clinical
RECRUITINGJacksonville, Florida, 32216, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nature Coast Clinical Research LLC
RECRUITINGInverness, Florida, 34452, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Synergy Healthcare
RECRUITINGBradenton, Florida, 34208, United States
Contact
Contact Email: •••••@•••••