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Heart pacing mimics exercise to boost weak hearts

NCT ID NCT06332391

Knowledge-focused Sponsor: Denice Hodgson-Zingman, MD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether pacing the heart to mimic the speed of a workout can improve heart function in people with heart failure. Fifty-two adults with a weak heart and an implanted defibrillator will receive either active pacing or a sham (fake) pacing for 6 weeks. Researchers will measure changes in heart pumping strength, symptoms, and quality of life to see if this approach could become a new therapy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exercise-similar cardiac pacing via implanted defibrillator
What this could lead to
If it works, this could point toward a drug-free way to strengthen the heart in people with heart failure.
What could go wrong
This is a small, early-phase study testing a concept, not a proven treatment. The pacing may not improve heart function or quality of life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 52 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Nov 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 120 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study * Male or female sex * Age 18 years or greater * Available transportation for study visits * Left ventricular ejection fraction \< or = 40% despite at least 3 months guideline-directed medial therapy * NYHA class II-III heart failure symptoms * Atrial-lead inclusive implantable cardioverter defibrillator or biventricular defibrillator in place \> 3 months * Intrinsic or biventricular paced QRS duration of \<= 120 milliseconds Exclusion Criteria: * Age \< 18 years * Inability to ambulate safely * Congenital or primary valve disease * Ongoing (not suppressed) atrial arrhythmias * Left ventricular thrombus * Severe peripheral arterial disease that limits mobility * Hospital admission for life-threatening condition (e.g. heart failure, stroke) in the past 3 months * Major surgery in the past 3 months or anticipated during the period of study * Ventricular pacing indication in the absence of biventricular pacing * Life expectancy \< 1 year * Hemodialysis * Hematocrit \< 30% * Severe chronic lung disease that limits activity or requires oxygen * Pregnancy * Implantable cardioverter defibrillator battery longevity \< 1 year * Vulnerable populations such as prisoners and institutionalized individuals

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Conditions

The condition(s) this trial relates to.

heart failure Motor Activity systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure, systolic

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Iowa Hospitals and Clinics

    RECRUITING

    Iowa City, Iowa, 52242, United States

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