HEART FAILURE, SYSTOLIC

This study compares two common heart procedures—bypass surgery (CABG) and stenting (PCI)—in 754 people with severe coronary artery disease and a weak heart pump. The goal is to see which approach better prevents death, stroke, heart attack, or the need for repeat procedures over …

This study tests a device called Aortix, placed inside the body to help the heart pump and remove excess fluid, in people hospitalized for worsening heart failure. It compares the device plus standard care to standard care alone (diuretics) in 320 patients who are not responding …

This study looks at whether training doctors to quickly start and adjust four types of heart failure medications while patients are still in the hospital leads to better long-term treatment. About 438 adults with heart failure and reduced pumping function will be followed after d…

This study tests whether adding acetazolamide or metolazone to standard treatment helps people with acute decompensated heart failure get rid of excess fluid faster. About 320 adults with severe fluid buildup will receive one of these drugs alongside usual care. The goal is to se…

This study looks at how your fitness level relates to the bacteria in your mouth and how well blood flows to your muscles. Researchers will collect mouth swabs, saliva, and have participants do a cycling test. The goal is to understand these connections in people with heart failu…

This study tests whether a special pacing pattern can give heart failure patients some of the benefits of exercise without actually exercising. 52 adults with a weak heart and an existing pacemaker will receive either the pacing pattern or a sham (fake) treatment for 6 weeks. Res…

This study is for adults with psoriasis who want to help researchers understand the link between psoriasis and heart disease. The goal is to see if certain heart tests and blood markers can predict future heart problems. Participants will be followed over time to track heart heal…

This study compares two ways of delivering cardiac rehabilitation: in-person sessions at a clinic and telehealth sessions done from home. Researchers want to see if both methods produce similar improvements in walking ability and quality of life for people with heart conditions. …

This study looks at how the heart handles the extreme head-down tilt used during robotic pelvic surgery. Researchers will monitor 80 patients—some with normal heart function and some with heart failure—to see how their hearts respond. The goal is to identify which patients are at…