New heart pump could help when diuretics fail in acute heart failure

NCT ID NCT05677100

Recruiting now Disease control Sponsor: Procyrion Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 05, 2026 · Updated 3 times

Summary

This study tests a device called Aortix, a small pump placed in the main artery, to help remove excess fluid in people hospitalized with acute heart failure who are not responding well to diuretic medications. About 320 participants will be randomly assigned to receive either the Aortix pump plus standard care or standard care alone. The goal is to see if the device improves fluid loss and reduces the risk of death or repeat hospitalizations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aortix System (a pump device placed in the aorta to help the heart and kidneys remove excess fluid)
What this could lead to: If successful, this device could offer a new option for heart failure patients who don't respond well to standard diuretics, potentially reducing hospital readmissions and improving fluid removal.
What could go wrong: This is an early-stage trial (no phase assigned) with 320 participants, so results may not apply to all patients. The device is invasive and carries risks like any implanted pump, including infection or device-related complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardio-renal syndrome congestive heart failure diastolic heart failure heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADHF CARDIO-RENAL SYNDROME CARDIORENAL SYNDROME HEART FAILURE HEART FAILURE, DIASTOLIC HEART FAILURE, SYSTOLIC HEART FAILURE; WITH DECOMPENSATION HEART FAILURE，CONGESTIVE

Contacts and locations

Locations

AdventHealth Tampa
RECRUITING

Tampa, Florida, 33613, United States
Advocate Aurora - Good Samaritan
ACTIVE_NOT_RECRUITING

Downers Grove, Illinois, 60515, United States
Advocate IMMC
RECRUITING

Chicago, Illinois, 60657, United States
AnMed Health
RECRUITING

Anderson, South Carolina, 29621, United States
Ascenscion Alexian Brothers
RECRUITING

Elk Grove Village, Illinois, 60007, United States
Ascension Sacred Heart
WITHDRAWN

Pensacola, Florida, 32504, United States
Ascension via Christi Kansas
TERMINATED

Wichita, Kansas, 67226, United States
Atrium Health Sanger Heart and Vascular Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Banner--University Medical Center Phoenix
RECRUITING

Phoenix, Arizona, 85006, United States
BayCare Medical/St. Joseph's Hospital
RECRUITING

Tampa, Florida, 33607, United States
Baylor Scott & White
WITHDRAWN

Fort Worth, Texas, 76104, United States
Baylor Scott & White
WITHDRAWN

Plano, Texas, 75093, United States
Cleveland Clinic Florida
RECRUITING

Weston, Florida, 33331, United States
Duke University Medical Center
ACTIVE_NOT_RECRUITING

Durham, North Carolina, 27710, United States
Emory University Hospital
RECRUITING

Atlanta, Georgia, 30308, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Henry Ford
RECRUITING

Detroit, Michigan, 48202, United States
HonorHealth Medical Center
TERMINATED

Scottsdale, Arizona, 85258, United States
Intermountain Health
WITHDRAWN

Murray, Utah, 84107, United States
Jefferson Abington Hospital
RECRUITING

Abington, Pennsylvania, 19001, United States
Jersey Shore University Medical Center
RECRUITING

Neptune City, New Jersey, 07753, United States
John Muir Health
RECRUITING

Concord, California, 94520, United States
Mayo Clinic - Arizona
RECRUITING

Phoenix, Arizona, 85054, United States
Mount Sinai Morningside
RECRUITING

New York, New York, 10025, United States
New York Presbyterian - Brooklyn Methodist Hospital
RECRUITING

Brooklyn, New York, 11215, United States
Northwell Health (Lenox Hill)
TERMINATED

New York, New York, 10075, United States
Northwell Health (Staten Island)
RECRUITING

Staten Island, New York, 10305, United States
Novant Health New Hanover Regional Medical Center
WITHDRAWN

Wilmington, North Carolina, 28401, United States
Nuvance Health
RECRUITING

Poughkeepsie, New York, 12601, United States
Nyph/Cumc
RECRUITING

New York, New York, 10032, United States
Oklahoma Cardiovascular Research Group
RECRUITING

Oklahoma City, Oklahoma, 73120, United States
Oregon Health & Sciences University
ACTIVE_NOT_RECRUITING

Portland, Oregon, 97239, United States
Penn Presbyterian Medical Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Piedmont Healthcare Inc.
RECRUITING

Augusta, Georgia, 30309, United States
San Francisco Veterans Administration
TERMINATED

San Francisco, California, 94121, United States
Semmelweis University
RECRUITING

Budapest, Hungary
Tallahassee Research Institute
TERMINATED

Tallahassee, Florida, 32308, United States
Texas Heart Institute
RECRUITING

Houston, Texas, 77030, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Thomas Jefferson University Hospital
ACTIVE_NOT_RECRUITING

Philadelphia, Pennsylvania, 19107, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States
University of Michigan, Cardiovascular Medicine
WITHDRAWN

Ann Arbor, Michigan, 48109, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of South Florida
RECRUITING

Tampa, Florida, 33606, United States
University of Virginia
TERMINATED

Charlottesville, Virginia, 22908, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23219, United States
Wellstar Research Institue
TERMINATED

Marietta, Georgia, 30060, United States
Zuckerberg San Francisco General
RECRUITING

San Francisco, California, 94110, United States

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