Heart failure fluid battle: which pill works better?
NCT ID NCT07199088
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests two water pills—acetazolamide and metolazone—added to standard diuretics in 320 adults hospitalized with acute decompensated heart failure. The goal is to see which drug clears fluid buildup faster and more safely, reducing hospital stays and complications. Participants receive one of the two pills daily, and doctors track decongestion, kidney function, and side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
acetazolamide and metolazone (diuretic drugs)
What this could lead to
If it works, this could identify a better add-on diuretic to help heart failure patients get rid of excess fluid faster and shorten hospital stays.
What could go wrong
This is a single-center study in Pakistan, so results may not apply to other populations. Both drugs can cause kidney problems or electrolyte imbalances, and the trial is not blinded, which could bias results.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Quaid e Azam Medical College , bahawalpur
RECRUITINGChak Four Hundred Fifty-four, Punjab Province, Pakistan
Contact Phone: •••-•••-•••• Email: •••••@•••••