Heart failure fluid battle: which pill works better?

NCT ID NCT07199088

Recruiting now Disease control Sponsor: University of Health Sciences Lahore Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two water pills—acetazolamide and metolazone—added to standard diuretics in 320 adults hospitalized with acute decompensated heart failure. The goal is to see which drug clears fluid buildup faster and more safely, reducing hospital stays and complications. Participants receive one of the two pills daily, and doctors track decongestion, kidney function, and side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: acetazolamide and metolazone (diuretic drugs)
What this could lead to: If it works, this could identify a better add-on diuretic to help heart failure patients get rid of excess fluid faster and shorten hospital stays.
What could go wrong: This is a single-center study in Pakistan, so results may not apply to other populations. Both drugs can cause kidney problems or electrolyte imbalances, and the trial is not blinded, which could bias results.

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Conditions

The condition(s) this trial relates to.

congestive heart failure diastolic heart failure heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE DECOMPENSATED HEART FAILURE HEART FAILURE, DIASTOLIC HEART FAILURE, SYSTOLIC

Contacts and locations

Locations

Quaid e Azam Medical College , bahawalpur
RECRUITING

Chak Four Hundred Fifty-four, Punjab Province, Pakistan

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