Heart failure fluid removal device trial halted early
NCT ID NCT05318105
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compared a device called Aquadex, which filters excess fluid from the blood, to standard IV diuretics in 167 hospitalized heart failure patients with fluid overload. The goal was to see which method better prevented heart failure events like rehospitalization. However, the trial was terminated early, so the results are incomplete and should be interpreted with caution.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Aquadex Smartflow System (a device that removes excess fluid from the blood) and IV loop diuretics (medication to increase urine output)
What this could lead to
If successful, this could provide a more effective way to remove excess fluid in heart failure patients, potentially reducing hospital readmissions.
What could go wrong
The trial was terminated early, meaning it did not complete as planned. This limits the reliability of any findings, and the device may not prove better than standard diuretics.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Abington Jefferson Health
Abington, Pennsylvania, 19001, United States
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Banner Health
Tucson, Arizona, 85721, United States
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BayCare Medical Group, Morton Plant
Clearwater, Florida, 33756, United States
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Baylor Scott & White Research Institute
Dallas, Texas, 75207, United States
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Henry Ford Health
Detroit, Michigan, 48202, United States
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Jackson Madison County General Hospital
Jackson, Tennessee, 38301, United States
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MemorialCare, Long Beach Medical Center
Long Beach, California, 90806, United States
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Mount Sinai Morningside
New York, New York, 10025, United States
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Northwell Health
New York, New York, 10075, United States
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Sentara Norfolk General Heart Hospital
Norfolk, Virginia, 23507, United States
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Sharp Memorial Hospital, San Diego Cardiac Center
San Diego, California, 92123, United States
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The Christ Hospital
Cincinnati, Ohio, 45219, United States
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The Mount Sinai Hospital
New York, New York, 10029, United States
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The Ohio State University
Columbus, Ohio, 43215, United States
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University of Kentucky
Lexington, Kentucky, 40536, United States