Could a simple pacemaker switch ease heart failure?

NCT ID NCT06052475

Recruiting now Disease control Sponsor: Imperial College London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether people with heart failure and a traditional right ventricular pacemaker feel better and have stronger hearts after switching to a more natural pacing method, such as His bundle or biventricular pacing. Participants will have their pacemaker upgraded and then spend time in both pacing modes, blinded, to compare symptoms, heart function, and quality of life. The study aims to see if a simple device change can reverse pacing-induced heart damage.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Physiological pacing upgrade (conduction system pacing or biventricular pacing device)
What this could lead to: If successful, this could show that upgrading pacemakers to a more natural pacing method improves heart function and daily well-being for people with pacing-induced cardiomyopathy.
What could go wrong: This is a relatively small crossover trial, and the benefits may not be large or apply to all patients. The procedure itself carries risks like infection or lead displacement.

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Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE PACING-INDUCED CARDIOMYOPATHY

Contacts and locations

Locations

Croydon University Hospital - Croydon Health Services
RECRUITING

Croydon, United Kingdom
Glenfield Hospital
RECRUITING

Leicester, United Kingdom
Great Western Hospitals
RECRUITING

Swindon, United Kingdom
Hammersmith Hospital
RECRUITING

London, United Kingdom
King's College Hospital
RECRUITING

London, United Kingdom
Oxford University Hospitals
RECRUITING

Oxford, United Kingdom
Royal Papworth Hospital
RECRUITING

Cambridge, United Kingdom
St Bartholomew's Hospital - Barts Health NHS Trust
RECRUITING

London, United Kingdom
St. Richard's Hospital - University Hospitals Sussex
RECRUITING

Chichester, United Kingdom
University Hospitals Coventry and Warwickshire NHS Trust,
RECRUITING

Coventry, United Kingdom
University Hospitals Southampton
RECRUITING

Southampton, United Kingdom
Worthing Hospital - University Hospitals Sussex
RECRUITING

Worthing, United Kingdom

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