Could a simple pacemaker switch ease heart failure?
NCT ID NCT06052475
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial investigates whether people with heart failure and a traditional right ventricular pacemaker feel better and have stronger hearts after switching to a more natural pacing method, such as His bundle or biventricular pacing. Participants will have their pacemaker upgraded and then spend time in both pacing modes, blinded, to compare symptoms, heart function, and quality of life. The study aims to see if a simple device change can reverse pacing-induced heart damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Physiological pacing upgrade (conduction system pacing or biventricular pacing device)
What this could lead to
If successful, this could show that upgrading pacemakers to a more natural pacing method improves heart function and daily well-being for people with pacing-induced cardiomyopathy.
What could go wrong
This is a relatively small crossover trial, and the benefits may not be large or apply to all patients. The procedure itself carries risks like infection or lead displacement.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Croydon University Hospital - Croydon Health Services
RECRUITINGCroydon, United Kingdom
Contact Email: •••••@•••••
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Glenfield Hospital
RECRUITINGLeicester, United Kingdom
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Great Western Hospitals
RECRUITINGSwindon, United Kingdom
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Hammersmith Hospital
RECRUITINGLondon, United Kingdom
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King's College Hospital
RECRUITINGLondon, United Kingdom
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Oxford University Hospitals
RECRUITINGOxford, United Kingdom
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Royal Papworth Hospital
RECRUITINGCambridge, United Kingdom
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St Bartholomew's Hospital - Barts Health NHS Trust
RECRUITINGLondon, United Kingdom
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St. Richard's Hospital - University Hospitals Sussex
RECRUITINGChichester, United Kingdom
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University Hospitals Coventry and Warwickshire NHS Trust,
RECRUITINGCoventry, United Kingdom
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University Hospitals Southampton
RECRUITINGSouthampton, United Kingdom
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Worthing Hospital - University Hospitals Sussex
RECRUITINGWorthing, United Kingdom
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