Yale study investigates diuretic resistance in heart failure

NCT ID NCT06209359

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at why some people with heart failure don't respond well to diuretics (water pills). Researchers will give 50 participants either ammonium chloride or a placebo, along with standard diuretics, to see how it affects kidney function. The goal is to understand the body's sodium handling better, which could improve future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ammonium chloride
What this could lead to: If successful, this could help doctors understand why some heart failure patients are resistant to diuretics, potentially leading to better treatment strategies.
What could go wrong: This is a small, early-phase study (50 participants) focused on understanding mechanisms, not on proving a new treatment works. Results may not apply to all heart failure patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiomyopathy heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIURETIC RESISTANCE HEART FAILURE

Contacts and locations

Locations

Yale University
RECRUITING

New Haven, Connecticut, 06510, United States

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