Heart pump could outperform drugs in advanced heart failure

NCT ID NCT04768322

Recruiting now Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a mechanical heart pump (LVAD) works better than standard medications for people with end-stage heart failure who are not yet bedridden. About 92 participants will either receive the pump or continue their current drug therapy. The goal is to see which approach improves survival, reduces urgent procedures, and boosts quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HeartMate 3 Left Ventricular Assist System (a mechanical heart pump)
What this could lead to: If successful, this could show that a heart pump is better than medications alone for some patients with advanced heart failure, potentially improving survival and reducing hospital stays.
What could go wrong: This is a small, early-stage trial with only 92 participants, so results may not apply to everyone. Heart pumps carry risks like infection, stroke, and bleeding.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

advanced heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

END-STAGE HEART FAILURE

Contacts and locations

Locations

Arnaud de Villeneuve Hospital / CHU Montpellier
RECRUITING

Montpellier, France
CHRU, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu
RECRUITING

Vandœuvre-lès-Nancy, France
CHU Besançon
RECRUITING

Besançon, France
CHU Caen
RECRUITING

Caen, France
CHU Rouen
RECRUITING

Rouen, France
CHU Tours
RECRUITING

Tours, France
Hôpital Pneumologique et Cardiovasculaire Louis Pradel
RECRUITING

Bron, France
La Tronche Hospital / CHU Grenoble
RECRUITING

La Tronche, France

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