Heart failure drug resistance: scientists test new combinations

NCT ID NCT05753059

Recruiting now Knowledge-focused Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at why some people with heart failure don't get rid of excess fluid with standard water pills (diuretics). Researchers will test adding two other types of diuretics—bendroflumethiazide and amiloride—to see if they improve the body's response. Fifty adults with heart failure will receive different drug combinations over several weeks to measure how well their kidneys remove salt and water.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bendroflumethiazide, amiloride, and bumetanide (diuretic drugs)
What this could lead to: If successful, this could help doctors choose better diuretic combinations for heart failure patients who don't respond to standard treatment.
What could go wrong: This is a small, early-phase study (50 people) focused on understanding mechanisms, not proving long-term benefits. Results may not apply to all heart failure patients.

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Conditions

The condition(s) this trial relates to.

heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Yale University
RECRUITING

New Haven, Connecticut, 06510, United States

Contact

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