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Can zapping the heart beat drugs for AF in heart failure?

NCT ID NCT01411371

NEW Symptom relief Sponsor: Barts & The London NHS Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers compare catheter ablation with medication for people who have heart failure and persistent atrial fibrillation. Half the participants receive ablation to restore normal heart rhythm, and half receive standard drugs to control rate or rhythm. The trial measures changes in heart pumping function and exercise capacity after six months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
catheter ablation, a procedure that uses heat or cold to scar heart tissue and restore normal rhythm
What this could lead to
If ablation works better than drugs, it could become a preferred way to treat atrial fibrillation in people with heart failure, possibly improving heart function and quality of life.
What could go wrong
This is a small trial of 50 people, so results may not apply broadly. Ablation carries risks like bleeding, infection, or damage to heart structures, and not everyone responds.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Start date

Mar 2005

Finished

Feb 2013

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Persistent atrial fibrillation * Symptomatic heart failure Exclusion Criteria: * Reversible causes of heart failure * Contraindications to catheter ablation

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Conditions

The condition(s) this trial relates to.

atrial fibrillation heart failure persistent atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrial fibrillation Heart failure

Contacts and locations

Locations

  • Barts & The London NHS Trust

    London, UK, EC1A 7BE, United Kingdom

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