Barts & The London Nhs Trust

This study tests a new two-step procedure for people with long-standing persistent atrial fibrillation (AFib), a type of irregular heartbeat. The procedure combines a minimally invasive surgery on the outside of the heart with a standard catheter ablation inside the heart. Resear…

This study tests a personalized approach to catheter ablation for persistent atrial fibrillation (AF), a common heart rhythm disorder. Researchers will identify specific areas in the heart that drive AF and target them with ablation, aiming to improve success rates. The trial inv…

This study compares two procedures for treating persistent atrial fibrillation (AF): catheter ablation (which scars tiny areas in the heart to block faulty signals) and DC cardioversion (an electric shock to restore normal rhythm). Researchers want to see which one better prevent…

This study tests a new method for placing spinal cord stimulators in people with chronic back pain. The device uses electrical recordings to confirm the lead is in the right spot. Twenty adults with long-term back pain will take part, and researchers will measure pain relief and …

This study tests whether a single infusion of a patient's own bone marrow stem cells can reduce chest pain and improve quality of life for people with refractory angina—a severe form of chest pain that doesn't respond to standard treatments. About 110 participants will be randoml…

This study aims to find new genes that cause pituitary tumors, including those that lead to acromegaly (gigantism) and prolactinomas. Researchers will collect blood and tissue samples from up to 10,000 people with these tumors and their family members. By analyzing DNA, they hope…

This study investigates whether certain genetic variations make some people with atrial fibrillation more likely to develop a weakened heart muscle (cardiomyopathy). Researchers will compare the DNA of 299 participants, including those with AF-related cardiomyopathy and control g…

This study looks at whether using continuous EEG (a brain wave monitor) in the ICU helps people with a severe, hard-to-stop seizure condition called refractory status epilepticus. Researchers will compare patients who get standard care plus continuous EEG to those who get standar…

This study follows 141 adults with atrial fibrillation and moderate-to-severe functional mitral or tricuspid valve regurgitation (leaky valves). Researchers will use echocardiograms, exercise tests, and blood work to identify patterns and predict how the disease progresses over o…

This study tests three different dental implant surfaces to see which one best preserves the bone around the implant and gives the best look. Thirty-nine adults needing a tooth replaced will get one of the three implant types. Researchers will measure bone changes and patient sat…

This study looks at how a heart rhythm treatment called catheter ablation affects the quality of life of people with ventricular tachycardia who have an implantable defibrillator. Researchers will ask 70 participants to fill out questionnaires about their health and well-being at…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …

This study looks at how muscle wasting in the mouth and throat affects swallowing in adults who are critically ill and in the intensive care unit. Researchers will measure muscle size and strength, and test swallowing safety at several points during the hospital stay. The goal is…

This study at St Bartholomew's Hospital is enrolling 160 people with persistent atrial fibrillation (AFib) who are scheduled for their first catheter ablation. Researchers will create detailed 3D electrical maps of the heart during the procedure to understand why AFib persists an…

This study looks at how genes affect the immune system and treatment responses in people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect blood samples from 300 patients to identify genetic patterns li…

This study aims to see if CT and echo scans taken before and after a TAVI procedure can help predict how the new heart valve will perform. Researchers will collect scan data from 40 adults with severe aortic stenosis and use it to train a computer algorithm. The goal is to improv…