Barts & The London Nhs Trust

This study tests a personalized approach to catheter ablation for persistent atrial fibrillation (AFib), a common heart rhythm disorder. Researchers will map individual electrical patterns in the heart to guide targeted ablation. The goal is to improve success rates and reduce th…

This study compares two treatments for persistent atrial fibrillation (AF), a heart rhythm problem. One treatment is catheter ablation, which uses heat to destroy tiny areas of heart tissue causing the irregular rhythm. The other is electrical cardioversion, which delivers a cont…

This study tests whether a person's own bone marrow stem cells can reduce chest pain and improve daily life for those with severe, untreatable angina. About 110 adults with persistent chest pain despite maximum medication will receive either a real stem cell infusion or a sham pr…

This study tests a new way to place spinal cord stimulators in 20 adults with chronic lower back pain. Doctors will use special recordings during the procedure to confirm the device is targeting the right nerve area. The goal is to improve pain relief and understand how well this…

This study looks at whether using continuous EEG (a brain wave test) in the ICU helps people with severe, hard-to-stop seizures. It compares those who get this monitoring to those who receive standard care. The goal is to see if it reduces hospital stays, deaths, and complication…

This study compares two types of dental implant surfaces to see which one better preserves the bone around the implant, looks more natural, and causes less inflammation. About 39 adults who need a single front tooth replaced will receive one of the two implant types. Researchers …

This study looks at how well treatments for a fast heart rhythm called ventricular tachycardia (VT) work by asking patients about their quality of life. About 70 adults with an implanted defibrillator (ICD) will fill out questionnaires before and after treatment, either with a ca…

This study looks at whether CT and echo scans taken before and after a TAVI heart valve procedure can help predict how the new valve will work over time. About 40 adults with severe aortic stenosis will get an extra CT scan six months after their procedure. The scan data will be …

This study looks at how a person's genes influence their immune response and recovery from cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect blood samples from 300 patients to identify genetic patterns linke…

This study looks at how muscle wasting in the mouth and throat affects swallowing in critically ill adults in the ICU. Researchers will measure muscle size and strength, and test swallowing safety in 160 patients. The goal is to find better ways to diagnose and treat swallowing p…

This study watches 100 adults who needed a machine called ECMO for severe heart or lung failure. Researchers want to see how muscle loss and weakness affect their recovery and quality of life. They will use ultrasound, strength tests, and questionnaires to track changes over time…

This study aims to find out if certain genetic differences make some people with atrial fibrillation (an irregular heartbeat) more likely to develop a weakened heart muscle (cardiomyopathy). Researchers will compare the DNA of 299 adults with and without this condition. The goal …

This study looks at how nutrition and body composition (like muscle mass) influence treatment results in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 patients starting new medical therapies or undergoi…

This study looks at why some people with persistent atrial fibrillation (a common heart rhythm problem) don't get lasting relief from standard ablation treatment. Researchers will create detailed 3D maps of the heart's electrical activity and scar areas during the procedure. By t…

This study follows 141 adults with atrial fibrillation and moderate-to-severe leakage of the mitral or tricuspid heart valves. Researchers will use echocardiograms and exercise tests to track how the valve disease changes over one year. The goal is to identify patterns and risk f…