Barts & The London Nhs Trust

This small pilot study tested whether adding a vitamin D-like drug called paricalcitol to standard chemotherapy could help people with advanced pancreatic cancer that had stopped responding. 27 patients received chemotherapy first, then paricalcitol was added if their disease sta…

This trial tested a steroid injection called triamcinolone in 55 men with castration resistant prostate cancer, a type that no longer responds to standard hormone therapy. The goal was to see if it could extend the time before chemotherapy is needed, since current steroid treatme…

This study tested a device called Reactiv8, implanted near the spine to stimulate back muscles in 20 adults with long-term low back pain. The goal was to see if it could reduce pain, improve daily function, and change how the brain and muscles respond. Researchers measured pain l…

This study aimed to create a new questionnaire that measures how atrial fibrillation (AF) affects a person's quality of life. Researchers worked with 206 adults who have AF to develop and test this tool. The goal was to better understand the real-world impact of AF beyond just me…

This small study looked at how occipital nerve stimulation (ONS) changes the way people with chronic migraine or cluster headache feel pain. Researchers used special tests and questionnaires to measure pain markers before and after ONS, and compared results to people having non-p…

This study compared two methods—CoolStick and ethyl chloride spray—for checking how well anesthesia numbs the skin before a planned C-section. 64 pregnant patients were included. The goal was to see which tool works better for measuring numbness to light touch and cold. This was …

This study looked at how heart surgery impacts the mental health, well-being, and quality of life of adults with Marfan Syndrome. Researchers asked 28 patients to fill out questionnaires about depression, fatigue, pain, and self-esteem before surgery and at several points after. …

This pilot study enrolled 5 people with hypertrophic cardiomyopathy who needed an implantable cardioverter defibrillator (ICD) but did not require pacing. Participants were randomly assigned to receive either a subcutaneous ICD (placed under the skin) or a transvenous ICD (with l…

This completed pilot study tested whether giving a daily multi-nutrient drink to people who recently had an ischemic stroke is practical and acceptable. Twenty-four adults were split into two groups: one received the drink plus standard care, the other standard care alone. The ma…