Vitamin d derivative tested as chemo booster for pancreatic cancer
NCT ID NCT04054362
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This small pilot study tested whether adding a vitamin D-like drug called paricalcitol to standard chemotherapy could help people with advanced pancreatic cancer that had stopped responding. 27 patients received chemotherapy first, then paricalcitol was added if their disease stabilized or worsened. The goal was to see if this combination could improve outcomes, but the study was very small and early-stage, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- paricalcitol (a form of vitamin D) added to chemotherapy (paclitaxel protein bound, gemcitabine, with or without cisplatin)
- What this could lead to
- If it works, this could point toward a way to improve chemotherapy response in advanced pancreatic cancer.
- What could go wrong
- This is a very small, early-phase pilot study with only 27 participants. It may not show clear benefit, and results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Barts Health NHS Trust
London, London, Greater, EC1M 6BQ, United Kingdom
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