Could your own bone marrow ease incurable chest pain?

NCT ID NCT05711849

Recruiting now Symptom relief Sponsor: Barts & The London NHS Trust Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a single infusion of a patient's own bone marrow stem cells can reduce chest pain and improve quality of life for people with refractory angina—a severe form of chest pain that doesn't respond to standard treatments. About 110 participants will be randomly assigned to receive either the real stem cell treatment or a sham procedure, and neither they nor their doctors will know which they got. The main goal is to see if angina symptoms improve over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: autologous bone marrow stem cells
What this could lead to: If it works, this could offer a new way to reduce chest pain and improve daily life for people with refractory angina who have few other options.
What could go wrong: This is a mid-stage trial with only 110 participants, so results may not apply to everyone. The procedure involves bone marrow collection and heart artery infusion, which carry risks like bleeding or infection.

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Conditions

The condition(s) this trial relates to.

Angina Pectoris intermediate coronary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY ANGINA REFRACTORY ANGINA PECTORIS

Contacts and locations

Locations

St Bartholomew's Hospital
RECRUITING

London, England, EC1A 7BE, United Kingdom

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