Could your own stem cells ease incurable chest pain?

NCT ID NCT03455725

Ongoing Disease control Sponsor: BioCardia, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This trial tests whether injecting a patient's own bone marrow stem cells into the heart can improve exercise ability and reduce chest pain in people with severe, untreatable angina. About 343 participants will either receive the stem cell treatment or a sham procedure. The goal is to see if this approach offers a new option for those who have not responded to standard therapies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: patient's own bone marrow stem cells
What this could lead to: If it works, this could offer a new treatment option for people with severe chest pain who have run out of standard options.
What could go wrong: This is a mid-stage trial, so results may not confirm benefit. The procedure involves heart injections, which carry risks like bleeding or heart damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Angina Pectoris myocardial ischemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC MYOCARDIAL ISCHEMIA REFRACTORY ANGINA

Contacts and locations

Locations

University of Florida

Gainesville, Florida, 32610, United States
University of Wisconsin Madison

Madison, Wisconsin, 53792, United States

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