Implantable device could offer new hope for patients with untreatable chest pain

NCT ID NCT05102019

Recruiting now Disease control Sponsor: Shockwave Medical, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This trial tests an implantable device called the Shockwave Reducer for people with severe, persistent chest pain (refractory angina) who cannot have standard treatments like stents or bypass surgery. About 380 participants will either receive the device or a sham procedure. The study measures changes in exercise ability and symptom relief over six months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Shockwave Reducer (implantable device)
What this could lead to: If it works, this device could offer a new option to reduce chest pain and improve exercise ability for people with refractory angina who have no other treatment choices.
What could go wrong: This is a mid-stage trial, so results are not yet proven. The device requires implantation, which carries risks like heart attack, bleeding, or need for further procedures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Angina Pectoris coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

REFRACTORY ANGINA

Contacts and locations

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Locations

Advocate Aurora Research Institute
RECRUITING

Milwaukee, Wisconsin, 53215, United States
Allegheny General Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Ascension Sacred Heart
RECRUITING

Pensacola, Florida, 32504, United States
Ascension St. John
RECRUITING

Tulsa, Oklahoma, 74104, United States
Ascension St. Vincent Heart Center
RECRUITING

Carmel, Indiana, 46920, United States
Ascension Texas Cardiovascular
RECRUITING

Austin, Texas, 78705, United States
Barts Health Centre
RECRUITING

London, E1 1FR, United Kingdom
Baystate Medical Center
RECRUITING

Springfield, Massachusetts, 01199, United States
Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02120, United States
Bristol Heart Institute
RECRUITING

Bristol, BS2 8HW, United Kingdom
CHUM
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Cardiology Associates of North Mississippi
WITHDRAWN

Tupelo, Mississippi, 38801, United States
Cardiovascular Institute of the South
RECRUITING

Houma, Louisiana, 70360, United States
Cardiovascular Research Institute of Kansas
WITHDRAWN

Wichita, Kansas, 67226, United States
Cedars-Sinai
RECRUITING

Los Angeles, California, 90048, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Medical Center/NYPH
RECRUITING

New York, New York, 10032, United States
Community Hospital - Munster
RECRUITING

Munster, Indiana, 46321, United States
Corewell Health
RECRUITING

Grand Rapids, Michigan, 59403, United States
Dorset County Hospital NHS Foundation Trust
RECRUITING

Dorchester, DT1 2JY, United Kingdom
Emory Hospital
RECRUITING

Atlanta, Georgia, 30308, United States
Essex Cardiothoracic Centre
RECRUITING

Basildon, SS16 5NL, United Kingdom
Freeman Hospital
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom
Glenfield Hospital, Leicester
RECRUITING

Leicester, LE3 9QP, United Kingdom
HCA Houston Healthcare Medical Center
WITHDRAWN

Houston, Texas, 77004, United States
Hackensack University
RECRUITING

Hackensack, New Jersey, 07601, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Henry Ford Providence
RECRUITING

Southfield, Michigan, 48075, United States
Henry Ford St. Johns
RECRUITING

Detroit, Michigan, 48236, United States
HonorHealth Research Institute
RECRUITING

Scottsdale, Arizona, 85258, United States
Houston Methodist
RECRUITING

Houston, Texas, 77030, United States
IUCPQ-Ulaval
RECRUITING

Québec, Quebec, G1V4G5, Canada
Imperial College Healthcare NHS Trust
RECRUITING

London, W12 0HS, United Kingdom
Jackson Heart Clinic
RECRUITING

Jackson, Mississippi, 39216, United States
Kaiser Permanente San Francisco
RECRUITING

San Francisco, California, 94115, United States
Kettering General Hospital
RECRUITING

Kettering, NN16 8UZ, United Kingdom
King's College Hospital
RECRUITING

London, SE5 9RS, United Kingdom
Liverpool Heart and Chest Hospital NHS Foundation Trust
RECRUITING

Liverpool, L14 3PE, United Kingdom
Long Beach VA Medical Center
WITHDRAWN

Long Beach, California, 90822, United States
Los Robles Hospital and Medical Center
RECRUITING

Thousand Oaks, California, 91360, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
MedStar Cardiovascular Research Network
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Medical City Fort Worth
RECRUITING

Fort Worth, Texas, 76104, United States
Methodist Hospital of San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
Minneapolis Heart Institute Foundation
RECRUITING

Minneapolis, Minnesota, 55407, United States
Mount Sinai Medical Center
RECRUITING

New York, New York, 10003, United States
Mount Sinai Miami
RECRUITING

Miami Beach, Florida, 33140, United States
Musgrove Park Hospital
RECRUITING

Taunton, TA1 5DA, United Kingdom

Contact Email: •••••@•••••
NCH Healthcare - Naples
RECRUITING

Naples, Florida, 34102, United States
NYU Langone
RECRUITING

New York, New York, 10010, United States
Northeast Georgia
RECRUITING

Gainesville, Georgia, 30501, United States
Northside Hospital
WITHDRAWN

Atlanta, Georgia, 30342, United States
Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Nottingham University Hospital
RECRUITING

Nottingham, NG5, United Kingdom
Novant Health
RECRUITING

Charlotte, North Carolina, 28204, United States
Oxford University Hospital
RECRUITING

Oxford, OX3 9DU, United Kingdom
Providence Heart Institute
RECRUITING

Portland, Oregon, 97225, United States
Queen Elizabeth Hospital Birmingham
RECRUITING

Birmingham, B15 2GW, United Kingdom
Royal Bournemouth Hospital
RECRUITING

Poole, BH15 2JB, United Kingdom
Royal Brompton Hospital
RECRUITING

London, SW3 6NP, United Kingdom
Royal Free Hospital
RECRUITING

London, NW3 2QG, United Kingdom
Royal Papworth Hospital
RECRUITING

Cambridge, |CB2 0AY, United Kingdom
Saint Luke's Hospital
RECRUITING

Kansas City, Missouri, 64111, United States
Sentara Norfolk General Hospital
RECRUITING

Norfolk, Virginia, 23507, United States
South Denver Cardiology Associates
RECRUITING

Littleton, Colorado, 80120, United States
Southern Illinois University
RECRUITING

Springfield, Illinois, 62781, United States
St. Francis Hospital
RECRUITING

Roslyn, New York, 11576, United States
St. Georges University Hospital
RECRUITING

London, SW17 0QT, United Kingdom
St. Thomas Hospital
RECRUITING

London, SE1 7EH, United Kingdom
Tallahassee Research Institute
RECRUITING

Tallahassee, Florida, 32308, United States
Tampa General - USF Cardiology
RECRUITING

Tampa, Florida, 33606, United States
Texas Heart Institute
RECRUITING

Houston, Texas, 77030, United States
The Cardiac and Vascular Institute
RECRUITING

Gainesville, Florida, 32605, United States
The Christ Hospital
RECRUITING

Cincinnati, Ohio, 45219, United States
The Heart Hospital Baylor Plano
RECRUITING

Plano, Texas, 75093, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Toronto General Hospital (UHN)
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
TriStar Centennial Medical Center
RECRUITING

Nashville, Tennessee, 37203, United States
UCSD
RECRUITING

San Diego, California, 92037, United States
UCSF
RECRUITING

San Francisco, California, 94117, United States
UF Health Jacksonville
RECRUITING

Jacksonville, Florida, 32209, United States
USC Keck School of Medicine
RECRUITING

Los Angeles, California, 90033, United States
University of Arizona Sarver Heart Center
RECRUITING

Tucson, Arizona, 85724, United States
University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Ottawa Heart Institute
RECRUITING

Ottawa, Ontario, K1y4W7, Canada
University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53792, United States
Vancouver General Hospital
RECRUITING

Vancouver, British Columbia, V521M9, Canada
Vanderbilt Heart
RECRUITING

Nashville, Tennessee, 37232, United States
Weill Cornell Medicine
RECRUITING

New York, New York, 10021, United States
Wellstar Kennestone Hospital
RECRUITING

Marietta, Georgia, 30062, United States
Yale University
RECRUITING

New Haven, Connecticut, 06519, United States

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