Heart showdown: which procedure boosts CRT best for AF and heart failure?

NCT ID NCT04664686

Recruiting now Disease control Sponsor: Guy's and St Thomas' NHS Foundation Trust Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing two different procedures—AF catheter ablation and AV node ablation—in 70 people who have heart failure, atrial fibrillation, and a CRT device that isn't pacing enough. The goal is to see which procedure better improves heart function and quality of life after 6 months. Participants will be randomly assigned to one of the two procedures and followed with echocardiograms and clinical checks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: AF catheter ablation or AV node ablation
What this could lead to: If successful, this study could show which procedure better restores heart function and quality of life in people with heart failure and atrial fibrillation who already have a CRT device.
What could go wrong: This is a small, early-stage trial with only 70 participants, so results may not apply to everyone. Both procedures carry risks such as bleeding, infection, or heart rhythm problems.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION HEART FAILURE

Contacts and locations

Locations

Guys and St Thomas' NHS Foundation Trust
RECRUITING

London, SE1 7EH, United Kingdom

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