Tiny RNA clues could help kids avoid heart transplant complications

NCT ID NCT06532890

Recruiting now Knowledge-focused Sponsor: Northwestern University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This study is looking at tiny molecules called microRNAs in the blood of children who have had a heart transplant. The goal is to find patterns that can predict which children are at risk for infection or rejection of the new heart. By understanding these patterns, doctors hope to better tailor immunosuppressive drugs to each child, improving their long-term health. The study will follow 150 children for at least one year after their transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could lead to better ways to monitor and adjust immunosuppression in children after heart transplant, potentially reducing infections and rejections.
What could go wrong: This is an observational study, not testing a new treatment. It may not directly improve outcomes, and the findings might not apply to all patients or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIAC FAILURE GRAFT REJECTION

Contacts and locations

Locations

Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Columbia University
RECRUITING

New York, New York, 10032, United States
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of Pittsburgh
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Vanderbilt University
RECRUITING

Nashville, Tennessee, 37232, United States

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