Lung transplant moms: does Baby's DNA raise rejection risk?

NCT ID NCT05689905

Completed Knowledge-focused Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether shared genetic markers (HLA) between a child and a lung donor increase the risk of organ rejection in mothers who had a lung transplant. Researchers collected DNA from children born to 11 transplant women in France between 2012 and 2021. The goal is to better understand pregnancy-related immune risks and improve future recommendations.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could help doctors give better advice to lung transplant women about pregnancy risks.
What could go wrong: This is a small, completed study (11 participants) that only looks back at past pregnancies. It cannot prove cause and effect, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

transplant rejection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GRAFT REJECTION LUNG TRANSPLANTATION PREGNANCY

Contacts and locations

Locations

AP-HM

Marseille, 13005, France
Bordeaux University Hospital

Bordeaux, 33000, France
Civils Hospitals Lyon

Lyon, 69002, France
Cochin Hospital (AP-HP)

Paris, 75014, France
Foch Hospital

Suresnes, 92150, France
Grenoble University Hospital

Grenoble, 38700, France
Marie Lannelongue Hospital (GHSJ)

Le Plessis-Robinson, 92350, France
Nantes University Hospital

Nantes, Loire Atlantique, 44093, France
Strasbourg University Hospital

Strasbourg, 67200, France

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