Mild heart failure

This study tests a small sensor implanted in a large vein near the heart to help doctors monitor fluid buildup in people with heart failure. The sensor sends daily readings so treatment can be adjusted early. The trial will compare standard care plus sensor guidance to standard c…

This study tests a special pacemaker setting called SyncAV, used with left bundle branch area pacing, in people with heart failure and a heart block. The goal is to see if this setting can improve the heart's electrical timing and pumping strength. About 50 adults who already nee…

This study tests a device that uses radiofrequency energy to treat high blood pressure in the lungs (pulmonary hypertension) in people with heart failure. The goal is to see if it can reduce serious heart events like hospitalizations or death. About 750 adults with stable heart f…

This trial tests a small sensor placed in the pulmonary artery (the blood vessel from the heart to the lungs) that wirelessly sends daily pressure readings to doctors. The goal is to help people with moderate heart failure (NYHA Class II or III) manage their condition at home and…

This study tests a new remote monitoring system called SmartSignalHF in 1132 adults with heart failure who have an implanted heart device (ICD or CRT-D). The goal is to see if this system can reduce deaths and hospital stays over 12 months compared to standard care. Participants …

This study is testing a small device called the MiniLung petite kit, which helps oxygenate blood and remove carbon dioxide in newborns and children weighing 2 to 8 kilograms who have severe breathing or heart failure. The device works with a console to temporarily take over the w…

This study tests a 12-week phone program that uses positive psychology and motivational interviewing to help 280 heart failure patients stick to their diet, exercise, and medications. Participants get weekly phone sessions and text messages. The goal is to see if this approach im…

This study tests a home-based cardiac rehabilitation program delivered through a custom mobile app for people with heart failure. Participants use the app for education, mindfulness, and physical activity guidance, plus periodic video calls with an exercise physiologist. The goal…

This study looks at whether two proteins released by a struggling heart can be detected in the blood during acute heart failure. Researchers will measure these proteins in about 500 adults—some with stable or worsening heart failure and some healthy—to see if higher levels relate…

This study looks at whether people with heart failure can reduce their intake of ultra-processed foods (like packaged snacks, sugary drinks, and fast food) and whether doing so improves their health. Participants will track their meals using a smartphone app and receive coaching …

Researchers at the University of Calgary are testing a new, non-invasive way to assess heart function using a handgrip exercise. The study involves 100 adults, half with heart failure and half without. Participants squeeze a device with maximum force for two minutes while sensors…

This study follows 100 adults who needed ECMO support for severe heart or lung failure. Researchers will track muscle size, strength, and quality of life over time to understand why some patients develop lasting weakness. No new treatments are being tested; the goal is to gather …