Could a simple salt boost heart failure Patients' exercise ability?

NCT ID NCT05562167

Recruiting now Symptom relief Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a daily capsule of potassium nitrate (KNO3) can improve leg muscle power and overall exercise capacity in people with heart failure. 75 adults with reduced heart function will take either KNO3 or a placebo for 6 weeks. Researchers will measure changes in treadmill exercise performance and muscle strength.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: potassium nitrate (KNO3)
What this could lead to: If it works, this could point toward a simple, daily supplement to help people with heart failure exercise more easily and feel better.
What could go wrong: This is an early phase 2 trial with only 75 people, so results may not apply to everyone. The supplement might not improve exercise or could cause side effects like stomach upset.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE

Contacts and locations

Locations

Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

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