New hope for kids with heart failure: drug trial aims to improve heart function
NCT ID NCT05714085
First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 4 times
Summary
This study tests whether the drug vericiguat can help children with heart failure caused by a weak left heart chamber. About 342 children aged 1 month to 18 years will receive either vericiguat or a placebo for 16 weeks. The main goal is to see if the drug lowers a key heart stress marker (NT-proBNP) in the blood, which would indicate better heart function.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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A.O.Universitaria Meyer ( Site 1600)
COMPLETEDFlorence, Tuscany, 50139, Italy
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Ankara Bilkent Şehir Hastanesi. ( Site 3300)
RECRUITINGAnkara, 06800, Turkey (Türkiye)
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Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universita ( Site 1004)
COMPLETEDParis, 75019, France
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Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone ( Site 1003)
COMPLETEDMarseille, Provence-Alpes-Côte d'Azur Region, 13005, France
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Astrid Lindgrens Barnsjukhus ( Site 3001)
RECRUITINGSolna, Stockholm County, 171 64, Sweden
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Auckland City Hospital ( Site 2000)
RECRUITINGAuckland, 1023, New Zealand
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Azienda Ospedale - Università Padova ( Site 1601)
RECRUITINGPadova, Veneto, 35128, Italy
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Baskent Universitesi Ankara Hastanesi ( Site 3301)
RECRUITINGAnkara, 06490, Turkey (Türkiye)
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Boston Children's Hospital ( Site 0035)
RECRUITINGBoston, Massachusetts, 02115, United States
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C.S. Mott Children's Hospital ( Site 0033)
RECRUITINGAnn Arbor, Michigan, 48109, United States
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CHU Bordeaux Haut-Leveque ( Site 1000)
COMPLETEDPessac, Aquitaine, 33600, France
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CHU Lille - Institut Coeur Poumon ( Site 1005)
COMPLETEDLille, Nord, 59037, France
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CINVEC Medica ( Site 1814)
RECRUITINGGuadalajara, Jalisco, 44690, Mexico
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Centre Hospitalier Régional de la Citadelle ( Site 0302)
RECRUITINGLiège, Liege, 4000, Belgium
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Centre Hospitalier Universitaire de Nantes - Hôpital Femme-Enfant-Adolescent Chu De Nantes ( Site 1002)
COMPLETEDNantes, Loire-Atlantique, 44093, France
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Centre intégré universitaire de santé et de services sociaux-Centre de recherche du CHUS ( Site 0502)
RECRUITINGSherbrooke, Quebec, J1H 5H4, Canada
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Centro de Atención e Investigación Clínica ( Site 1813)
RECRUITINGAguascalientes, 20129, Mexico
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Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 1800)
RECRUITINGCiudad Madero, Tamaulipas, 89440, Mexico
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Children's Health Ireland (CHI) at Crumlin ( Site 1400)
RECRUITINGDublin, D12 N512, Ireland
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Children's Health-The Heart Center ( Site 0015)
RECRUITINGDallas, Texas, 75235, United States
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Children's Healthcare of Atlanta - Arthur M. Blank Hospital ( Site 0001)
RECRUITINGAtlanta, Georgia, 30329, United States
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Children's Heart Disease Research Unit ( Site 2704)
RECRUITINGCape Town, Western Cape, 7700, South Africa
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Children's Hospital Colorado ( Site 0012)
RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital of Philadelphia (CHOP) ( Site 0004)
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's Hospital of Pittsburgh ( Site 0010)
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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Children's National Medical Center ( Site 0020)
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Childrens University Hospital ( Site 4200)
RECRUITINGBelgrade, Beograd, 11000, Serbia
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Ciensalud Ips S A S ( Site 0608)
RECRUITINGBarranquilla, Atlántico, 08001, Colombia
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Cincinnati Children's Hospital Medical Center ( Site 0034)
RECRUITINGCincinnati, Ohio, 45229, United States
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Cleveland Clinic-Cleveland Clinic Chidren's ( Site 0022)
RECRUITINGCleveland, Ohio, 44195, United States
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Clinica Somer ( Site 0607)
RECRUITINGRionegro, Antioquia, 054040, Colombia
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Clínica Imbanaco S.A.S ( Site 0602)
RECRUITINGCali, Valle del Cauca Department, 760042, Colombia
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Columbia University Medical Center-Pediatric Cardiology ( Site 0016)
RECRUITINGNew York, New York, 10032, United States
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Deutsches Herzzentrum Berlin ( Site 1101)
RECRUITINGBerlin, 13353, Germany
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Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 3302)
RECRUITINGIstanbul, 34668, Turkey (Türkiye)
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Erasmus Medisch Centrum ( Site 1900)
RECRUITINGRotterdam, South Holland, 3015 CN, Netherlands
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Faculty of Medicine - Khon Kaen University ( Site 3202)
COMPLETEDMuang, Changwat Khon Kaen, 40002, Thailand
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Faculty of Medicine Siriraj Hospital ( Site 3200)
RECRUITINGBangkoknoi, Bangkok, 10700, Thailand
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Freeman Hospital ( Site 3400)
RECRUITINGNewcastle upon Tyne, NE7 7DN, United Kingdom
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Fundación Cardioinfantil Instituto de Cardiología ( Site 0603)
RECRUITINGBogotá, Bogota D.C., 110131, Colombia
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Fundación Valle del Lili ( Site 0604)
RECRUITINGCali, Valle del Cauca Department, 760032, Colombia
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Gottsegen György Országos Kardiovaszkuláris Intézet-Gyermeksziv Kozpont ( Site 1300)
RECRUITINGBudapest, 1096, Hungary
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Great Ormond Street Hospital For Children NHS Foundation Trust ( Site 3401)
RECRUITINGLondon, London, City of, WC1N 3JH, United Kingdom
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HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 2904)
RECRUITINGMadrid, Madrid, Comunidad de, 28007, Spain
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HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 2907)
RECRUITINGSeville, 41013, Spain
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Hacettepe Universite Hastaneleri ( Site 3304)
RECRUITINGAnkara, 06230, Turkey (Türkiye)
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Hospital Materno-Infantil Teresa Herrera ( Site 2905)
RECRUITINGA Coruña, La Coruna, 15009, Spain
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Hospital Queen Elizabeth II ( Site 1706)
RECRUITINGKota Kinabalu, Sabah, Kota Kinab, Malaysia
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Hospital Sant Joan de Déu-Pediatric cardiology ( Site 2902)
RECRUITINGEsplugues de Llobregat, Barcelona, 08950, Spain
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Hospital Tunku Azizah-Paediatric ( Site 1700)
RECRUITINGKuala Lumpur, 50300, Malaysia
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Hospital Universitari Vall d'Hebron ( Site 2903)
RECRUITINGBarcelona, Catalonia, 08035, Spain
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Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Pediatria ( Site 1816)
RECRUITINGMonterrey, Nuevo León, 66460, Mexico
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Hospital Universitario La Paz ( Site 2912)
RECRUITINGMadrid, 28046, Spain
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Hospital Universiti Sains Malaysia ( Site 1703)
RECRUITINGKota Bharu, Kelantan, 16150, Malaysia
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Hôpital Universitaire Necker Enfants Malades ( Site 1001)
COMPLETEDParis, 75015, France
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INVECORDIS S.C. ( Site 1808)
RECRUITINGHacienda de Las Palmas, State of Mexico, 52763, Mexico
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IRCCS Istituto Giannina Gaslini ( Site 1603)
RECRUITINGGenoa, Liguria, 16147, Italy
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Incor - Instituto do Coracao ( Site 0400)
RECRUITINGSão Paulo, 05403-900, Brazil
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Institut Jantung Negara ( Site 1705)
RECRUITINGKuala Lumpur, 50400, Malaysia
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Institut za zdravstvenu zastitu majke i deteta Srbije ( Site 4220)
RECRUITINGBelgrade, Beograd, 11000, Serbia
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Institute for Child and Youth Helth Care of Vojvodina ( Site 4210)
RECRUITINGNovi Sad, Vojvodina, 21000, Serbia
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Instituto Dante Pazzanese de Cardiology ( Site 0402)
RECRUITINGSão Paulo, São Paulo, 04012-909, Brazil
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Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2100)
COMPLETEDJesús María, Lima, 15072, Peru
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Instituto Nacional de Cardiologia Ignacio Chavez ( Site 1804)
RECRUITINGMéxico, 14080, Mexico
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Instituto Nacional de Pediatria ( Site 1803)
RECRUITINGMexico City, Mexico City, 04530, Mexico
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Johns Hopkins All Children's Hospital ( Site 0029)
RECRUITINGSt. Petersburg, Florida, 33701, United States
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KK Women's and Children's Hospital ( Site 2601)
RECRUITINGSingapore, South West, 229899, Singapore
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Kinderklinik des Uni-Klinikums Erlangen ( Site 1104)
RECRUITINGErlangen, Bavaria, 91054, Germany
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King Faisal Specialist Hospital and Research Center ( Site 4100)
RECRUITINGRiyadh, Riyadh Region, 12713, Saudi Arabia
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Klinički bolnički centar Zagreb ( Site 3700)
RECRUITINGZagreb, City of Zagreb, 10000, Croatia
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Le Bonheur Children's Hospital ( Site 0007)
RECRUITINGMemphis, Tennessee, 38103, United States
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Loma Linda University Health System ( Site 0008)
RECRUITINGSan Bernardino, California, 92408, United States
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Lucile Packard Children's Hospital ( Site 0040)
RECRUITINGPalo Alto, California, 94304, United States
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Maharaj Nakorn Chiang Mai Hospital-Department of Pediatrics ( Site 3201)
RECRUITINGChiang Mai, 50200, Thailand
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Medizinische Hochschule Hannover ( Site 1108)
RECRUITINGHanover, Lower Saxony, 30625, Germany
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Morales Vargas Centro de Investigacion S. C. ( Site 1810)
RECRUITINGLeón, Guanajuato, 37000, Mexico
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National University Hospital-Paediatrics ( Site 2600)
RECRUITINGSingapore, South West, 119074, Singapore
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Ospedale Infantile Regina Margherita ( Site 1604)
RECRUITINGTurin, Piedmont, 10126, Italy
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Ospedale Pediatrico Bambino Gesù IRCCS ( Site 1602)
RECRUITINGRome, Roma, 00165, Italy
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Ospedale dei Bambini "Vittore Buzzi" ( Site 1606)
RECRUITINGMilan, Lombardy, 20154, Italy
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Pusan National University Yangsan Hospital ( Site 2802)
RECRUITINGPusan, Kyongsangnam-do, 50612, South Korea
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Rigshospitalet-BørneUngeAfdelingen ( Site 0800)
RECRUITINGCopenhagen, Capital Region, DK-2100, Denmark
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S.B.Ü. DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ EĞİTİM VE ARAŞTIRMA HASTANESİ ( Site 3303)
RECRUITINGIzmir, 35210, Turkey (Türkiye)
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Samsung Medical Center ( Site 2801)
RECRUITINGSeoul, 06351, South Korea
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Seattle Children's Hospital-Cardiology/Fetal Therapy ( Site 0019)
RECRUITINGSeattle, Washington, 98105, United States
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Seoul National University Hospital ( Site 2803)
RECRUITINGSeoul, 03080, South Korea
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Severance Hospital, Yonsei University Health System ( Site 2800)
RECRUITINGSeoul, 03722, South Korea
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Skånes Universitetssjukhus Lund ( Site 3000)
RECRUITINGLund, Skåne County, 22185, Sweden
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Stollery Children's Hospital ( Site 0501)
RECRUITINGEdmonton, Alberta, T6G 2B7, Canada
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TREAD Research ( Site 2700)
COMPLETEDCape Town, Western Cape, 7500, South Africa
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Tampereen yliopistollinen sairaala-Pediatric Early Phase Trials Unit ( Site 0900)
RECRUITINGTampere, Pirkanmaa, 33520, Finland
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Texas Children's Hospital ( Site 0039)
RECRUITINGHouston, Texas, 77030, United States
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The Children's Hospital at Montefiore ( Site 0030)
RECRUITINGThe Bronx, New York, 10467, United States
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The Hospital for Sick Children ( Site 0500)
RECRUITINGToronto, Ontario, M5G 1X8, Canada
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The Regents of the University of California - Los Angeles (UCLA Pediatrics) ( Site 0002)
RECRUITINGLos Angeles, California, 90095, United States
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UROLAP ( Site 1812)
RECRUITINGColima, 28000, Mexico
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UZ Gent ( Site 0301)
RECRUITINGGhent, Oost-Vlaanderen, 9000, Belgium
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UZ Leuven ( Site 0300)
RECRUITINGLeuven, Vlaams-Brabant, 3000, Belgium
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Unidade Local de Saude Lisboa Ocidental - Hospital de Santa Cruz ( Site 2401)
RECRUITINGLisbon, Lisbon District, 2790-134, Portugal
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Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 2402)
RECRUITINGLisbon, 1649-035, Portugal
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Unidade Local de Saúde de São João ( Site 2403)
RECRUITINGPorto, 4200-319, Portugal
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Universitaetsklinikum Freiburg ( Site 1102)
RECRUITINGFreiburg im Breisgau, Baden-Wurttemberg, 79106, Germany
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Universitaetsklinikum Heidelberg ( Site 1100)
COMPLETEDHeidelberg, Baden-Wurttemberg, 69120, Germany
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Universitair Medisch Centrum Utrecht ( Site 1902)
RECRUITINGUtrecht, 3584 CX, Netherlands
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University Malaya Medical Centre ( Site 1701)
RECRUITINGLembah Pantai, Kuala Lumpur, 59100, Malaysia
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University Medical Center Groningen ( Site 1901)
RECRUITINGGroningen, 9713 GZ, Netherlands
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Uniwersyteckie Centrum Kliniczne-Klinika Kardiologii Dziecięcej i Wad Wrodzonych Serca ( Site 2302)
COMPLETEDGdansk, Pomeranian Voivodeship, 80-952, Poland
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Washington University-Pediatric Cardiology/ St. Louis Children's Hospital ( Site 0006)
RECRUITINGSt Louis, Missouri, 63110, United States
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