New hope for kids with heart failure: drug trial aims to improve heart function

NCT ID NCT05714085

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 4 times

Summary

This study tests whether the drug vericiguat can help children with heart failure caused by a weak left heart chamber. About 342 children aged 1 month to 18 years will receive either vericiguat or a placebo for 16 weeks. The main goal is to see if the drug lowers a key heart stress marker (NT-proBNP) in the blood, which would indicate better heart function.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • A.O.Universitaria Meyer ( Site 1600)

    COMPLETED

    Florence, Tuscany, 50139, Italy

  • Ankara Bilkent Şehir Hastanesi. ( Site 3300)

    RECRUITING

    Ankara, 06800, Turkey (Türkiye)

  • Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universita ( Site 1004)

    COMPLETED

    Paris, 75019, France

  • Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone ( Site 1003)

    COMPLETED

    Marseille, Provence-Alpes-Côte d'Azur Region, 13005, France

  • Astrid Lindgrens Barnsjukhus ( Site 3001)

    RECRUITING

    Solna, Stockholm County, 171 64, Sweden

  • Auckland City Hospital ( Site 2000)

    RECRUITING

    Auckland, 1023, New Zealand

  • Azienda Ospedale - Università Padova ( Site 1601)

    RECRUITING

    Padova, Veneto, 35128, Italy

  • Baskent Universitesi Ankara Hastanesi ( Site 3301)

    RECRUITING

    Ankara, 06490, Turkey (Türkiye)

  • Boston Children's Hospital ( Site 0035)

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • C.S. Mott Children's Hospital ( Site 0033)

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • CHU Bordeaux Haut-Leveque ( Site 1000)

    COMPLETED

    Pessac, Aquitaine, 33600, France

  • CHU Lille - Institut Coeur Poumon ( Site 1005)

    COMPLETED

    Lille, Nord, 59037, France

  • CINVEC Medica ( Site 1814)

    RECRUITING

    Guadalajara, Jalisco, 44690, Mexico

  • Centre Hospitalier Régional de la Citadelle ( Site 0302)

    RECRUITING

    Liège, Liege, 4000, Belgium

  • Centre Hospitalier Universitaire de Nantes - Hôpital Femme-Enfant-Adolescent Chu De Nantes ( Site 1002)

    COMPLETED

    Nantes, Loire-Atlantique, 44093, France

  • Centre intégré universitaire de santé et de services sociaux-Centre de recherche du CHUS ( Site 0502)

    RECRUITING

    Sherbrooke, Quebec, J1H 5H4, Canada

  • Centro de Atención e Investigación Clínica ( Site 1813)

    RECRUITING

    Aguascalientes, 20129, Mexico

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 1800)

    RECRUITING

    Ciudad Madero, Tamaulipas, 89440, Mexico

  • Children's Health Ireland (CHI) at Crumlin ( Site 1400)

    RECRUITING

    Dublin, D12 N512, Ireland

  • Children's Health-The Heart Center ( Site 0015)

    RECRUITING

    Dallas, Texas, 75235, United States

  • Children's Healthcare of Atlanta - Arthur M. Blank Hospital ( Site 0001)

    RECRUITING

    Atlanta, Georgia, 30329, United States

  • Children's Heart Disease Research Unit ( Site 2704)

    RECRUITING

    Cape Town, Western Cape, 7700, South Africa

  • Children's Hospital Colorado ( Site 0012)

    RECRUITING

    Aurora, Colorado, 80045, United States

  • Children's Hospital of Philadelphia (CHOP) ( Site 0004)

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital of Pittsburgh ( Site 0010)

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

  • Children's National Medical Center ( Site 0020)

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Childrens University Hospital ( Site 4200)

    RECRUITING

    Belgrade, Beograd, 11000, Serbia

  • Ciensalud Ips S A S ( Site 0608)

    RECRUITING

    Barranquilla, Atlántico, 08001, Colombia

  • Cincinnati Children's Hospital Medical Center ( Site 0034)

    RECRUITING

    Cincinnati, Ohio, 45229, United States

  • Cleveland Clinic-Cleveland Clinic Chidren's ( Site 0022)

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Clinica Somer ( Site 0607)

    RECRUITING

    Rionegro, Antioquia, 054040, Colombia

  • Clínica Imbanaco S.A.S ( Site 0602)

    RECRUITING

    Cali, Valle del Cauca Department, 760042, Colombia

  • Columbia University Medical Center-Pediatric Cardiology ( Site 0016)

    RECRUITING

    New York, New York, 10032, United States

  • Deutsches Herzzentrum Berlin ( Site 1101)

    RECRUITING

    Berlin, 13353, Germany

  • Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 3302)

    RECRUITING

    Istanbul, 34668, Turkey (Türkiye)

  • Erasmus Medisch Centrum ( Site 1900)

    RECRUITING

    Rotterdam, South Holland, 3015 CN, Netherlands

  • Faculty of Medicine - Khon Kaen University ( Site 3202)

    COMPLETED

    Muang, Changwat Khon Kaen, 40002, Thailand

  • Faculty of Medicine Siriraj Hospital ( Site 3200)

    RECRUITING

    Bangkoknoi, Bangkok, 10700, Thailand

  • Freeman Hospital ( Site 3400)

    RECRUITING

    Newcastle upon Tyne, NE7 7DN, United Kingdom

  • Fundación Cardioinfantil Instituto de Cardiología ( Site 0603)

    RECRUITING

    Bogotá, Bogota D.C., 110131, Colombia

  • Fundación Valle del Lili ( Site 0604)

    RECRUITING

    Cali, Valle del Cauca Department, 760032, Colombia

  • Gottsegen György Országos Kardiovaszkuláris Intézet-Gyermeksziv Kozpont ( Site 1300)

    RECRUITING

    Budapest, 1096, Hungary

  • Great Ormond Street Hospital For Children NHS Foundation Trust ( Site 3401)

    RECRUITING

    London, London, City of, WC1N 3JH, United Kingdom

  • HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON ( Site 2904)

    RECRUITING

    Madrid, Madrid, Comunidad de, 28007, Spain

  • HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO ( Site 2907)

    RECRUITING

    Seville, 41013, Spain

  • Hacettepe Universite Hastaneleri ( Site 3304)

    RECRUITING

    Ankara, 06230, Turkey (Türkiye)

  • Hospital Materno-Infantil Teresa Herrera ( Site 2905)

    RECRUITING

    A Coruña, La Coruna, 15009, Spain

  • Hospital Queen Elizabeth II ( Site 1706)

    RECRUITING

    Kota Kinabalu, Sabah, Kota Kinab, Malaysia

  • Hospital Sant Joan de Déu-Pediatric cardiology ( Site 2902)

    RECRUITING

    Esplugues de Llobregat, Barcelona, 08950, Spain

  • Hospital Tunku Azizah-Paediatric ( Site 1700)

    RECRUITING

    Kuala Lumpur, 50300, Malaysia

  • Hospital Universitari Vall d'Hebron ( Site 2903)

    RECRUITING

    Barcelona, Catalonia, 08035, Spain

  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"-Pediatria ( Site 1816)

    RECRUITING

    Monterrey, Nuevo León, 66460, Mexico

  • Hospital Universitario La Paz ( Site 2912)

    RECRUITING

    Madrid, 28046, Spain

  • Hospital Universiti Sains Malaysia ( Site 1703)

    RECRUITING

    Kota Bharu, Kelantan, 16150, Malaysia

  • Hôpital Universitaire Necker Enfants Malades ( Site 1001)

    COMPLETED

    Paris, 75015, France

  • INVECORDIS S.C. ( Site 1808)

    RECRUITING

    Hacienda de Las Palmas, State of Mexico, 52763, Mexico

  • IRCCS Istituto Giannina Gaslini ( Site 1603)

    RECRUITING

    Genoa, Liguria, 16147, Italy

  • Incor - Instituto do Coracao ( Site 0400)

    RECRUITING

    São Paulo, 05403-900, Brazil

  • Institut Jantung Negara ( Site 1705)

    RECRUITING

    Kuala Lumpur, 50400, Malaysia

  • Institut za zdravstvenu zastitu majke i deteta Srbije ( Site 4220)

    RECRUITING

    Belgrade, Beograd, 11000, Serbia

  • Institute for Child and Youth Helth Care of Vojvodina ( Site 4210)

    RECRUITING

    Novi Sad, Vojvodina, 21000, Serbia

  • Instituto Dante Pazzanese de Cardiology ( Site 0402)

    RECRUITING

    São Paulo, São Paulo, 04012-909, Brazil

  • Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2100)

    COMPLETED

    Jesús María, Lima, 15072, Peru

  • Instituto Nacional de Cardiologia Ignacio Chavez ( Site 1804)

    RECRUITING

    México, 14080, Mexico

  • Instituto Nacional de Pediatria ( Site 1803)

    RECRUITING

    Mexico City, Mexico City, 04530, Mexico

  • Johns Hopkins All Children's Hospital ( Site 0029)

    RECRUITING

    St. Petersburg, Florida, 33701, United States

  • KK Women's and Children's Hospital ( Site 2601)

    RECRUITING

    Singapore, South West, 229899, Singapore

  • Kinderklinik des Uni-Klinikums Erlangen ( Site 1104)

    RECRUITING

    Erlangen, Bavaria, 91054, Germany

  • King Faisal Specialist Hospital and Research Center ( Site 4100)

    RECRUITING

    Riyadh, Riyadh Region, 12713, Saudi Arabia

  • Klinički bolnički centar Zagreb ( Site 3700)

    RECRUITING

    Zagreb, City of Zagreb, 10000, Croatia

  • Le Bonheur Children's Hospital ( Site 0007)

    RECRUITING

    Memphis, Tennessee, 38103, United States

  • Loma Linda University Health System ( Site 0008)

    RECRUITING

    San Bernardino, California, 92408, United States

  • Lucile Packard Children's Hospital ( Site 0040)

    RECRUITING

    Palo Alto, California, 94304, United States

  • Maharaj Nakorn Chiang Mai Hospital-Department of Pediatrics ( Site 3201)

    RECRUITING

    Chiang Mai, 50200, Thailand

  • Medizinische Hochschule Hannover ( Site 1108)

    RECRUITING

    Hanover, Lower Saxony, 30625, Germany

  • Morales Vargas Centro de Investigacion S. C. ( Site 1810)

    RECRUITING

    León, Guanajuato, 37000, Mexico

  • National University Hospital-Paediatrics ( Site 2600)

    RECRUITING

    Singapore, South West, 119074, Singapore

  • Ospedale Infantile Regina Margherita ( Site 1604)

    RECRUITING

    Turin, Piedmont, 10126, Italy

  • Ospedale Pediatrico Bambino Gesù IRCCS ( Site 1602)

    RECRUITING

    Rome, Roma, 00165, Italy

  • Ospedale dei Bambini "Vittore Buzzi" ( Site 1606)

    RECRUITING

    Milan, Lombardy, 20154, Italy

  • Pusan National University Yangsan Hospital ( Site 2802)

    RECRUITING

    Pusan, Kyongsangnam-do, 50612, South Korea

  • Rigshospitalet-BørneUngeAfdelingen ( Site 0800)

    RECRUITING

    Copenhagen, Capital Region, DK-2100, Denmark

  • S.B.Ü. DR. BEHÇET UZ ÇOCUK HASTALIKLARI VE CERRAHİSİ EĞİTİM VE ARAŞTIRMA HASTANESİ ( Site 3303)

    RECRUITING

    Izmir, 35210, Turkey (Türkiye)

  • Samsung Medical Center ( Site 2801)

    RECRUITING

    Seoul, 06351, South Korea

  • Seattle Children's Hospital-Cardiology/Fetal Therapy ( Site 0019)

    RECRUITING

    Seattle, Washington, 98105, United States

  • Seoul National University Hospital ( Site 2803)

    RECRUITING

    Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System ( Site 2800)

    RECRUITING

    Seoul, 03722, South Korea

  • Skånes Universitetssjukhus Lund ( Site 3000)

    RECRUITING

    Lund, Skåne County, 22185, Sweden

  • Stollery Children's Hospital ( Site 0501)

    RECRUITING

    Edmonton, Alberta, T6G 2B7, Canada

  • TREAD Research ( Site 2700)

    COMPLETED

    Cape Town, Western Cape, 7500, South Africa

  • Tampereen yliopistollinen sairaala-Pediatric Early Phase Trials Unit ( Site 0900)

    RECRUITING

    Tampere, Pirkanmaa, 33520, Finland

  • Texas Children's Hospital ( Site 0039)

    RECRUITING

    Houston, Texas, 77030, United States

  • The Children's Hospital at Montefiore ( Site 0030)

    RECRUITING

    The Bronx, New York, 10467, United States

  • The Hospital for Sick Children ( Site 0500)

    RECRUITING

    Toronto, Ontario, M5G 1X8, Canada

  • The Regents of the University of California - Los Angeles (UCLA Pediatrics) ( Site 0002)

    RECRUITING

    Los Angeles, California, 90095, United States

  • UROLAP ( Site 1812)

    RECRUITING

    Colima, 28000, Mexico

  • UZ Gent ( Site 0301)

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • UZ Leuven ( Site 0300)

    RECRUITING

    Leuven, Vlaams-Brabant, 3000, Belgium

  • Unidade Local de Saude Lisboa Ocidental - Hospital de Santa Cruz ( Site 2401)

    RECRUITING

    Lisbon, Lisbon District, 2790-134, Portugal

  • Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 2402)

    RECRUITING

    Lisbon, 1649-035, Portugal

  • Unidade Local de Saúde de São João ( Site 2403)

    RECRUITING

    Porto, 4200-319, Portugal

  • Universitaetsklinikum Freiburg ( Site 1102)

    RECRUITING

    Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

  • Universitaetsklinikum Heidelberg ( Site 1100)

    COMPLETED

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Universitair Medisch Centrum Utrecht ( Site 1902)

    RECRUITING

    Utrecht, 3584 CX, Netherlands

  • University Malaya Medical Centre ( Site 1701)

    RECRUITING

    Lembah Pantai, Kuala Lumpur, 59100, Malaysia

  • University Medical Center Groningen ( Site 1901)

    RECRUITING

    Groningen, 9713 GZ, Netherlands

  • Uniwersyteckie Centrum Kliniczne-Klinika Kardiologii Dziecięcej i Wad Wrodzonych Serca ( Site 2302)

    COMPLETED

    Gdansk, Pomeranian Voivodeship, 80-952, Poland

  • Washington University-Pediatric Cardiology/ St. Louis Children's Hospital ( Site 0006)

    RECRUITING

    St Louis, Missouri, 63110, United States

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