Could dropping aspirin cut bleeding in LVAD patients?

NCT ID NCT06655376

Recruiting now Disease control Sponsor: Columbia University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at 128 people with advanced heart failure who have a HeartMate3 heart pump. All take warfarin to prevent clots, and half will also stop taking aspirin. The goal is to see if skipping aspirin lowers the risk of serious bleeding without raising the chance of dangerous clots or strokes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Aspirin and warfarin
What this could lead to: If successful, this could show that many LVAD patients can safely avoid aspirin, lowering their risk of serious bleeding without increasing clots.
What could go wrong: This is a relatively small Phase 4 trial (128 people) and only includes patients already stable on an LVAD for over 3 months, so results may not apply to everyone. Skipping aspirin might still raise clot risk in some individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

advanced heart failure Hemorrhage hemorrhagic disease thrombotic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLEEDING CLOT BLOOD

Contacts and locations

Locations

Columbia Irving Medical Center
RECRUITING

New York, New York, 10032, United States
The University of Texas Health Science Center at Houston
RECRUITING

Houston, Texas, 77030, United States
University of Chicago
RECRUITING

Chicago, Illinois, 60637, United States

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